• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy
【24h】

A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy

机译：具有高性能实时序贯低氧肿瘤治疗的实时监测能力的生物相容性自由基纳米发生器。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hypoxic microenvironment severely reduces therapeutic efficacy of oxygen-dependent photodynamic therapy in solid tumor due to the hampered cytotoxic oxygen radicals generation. Herein, a biocompatible nanoparticle (NP) is developed by combining bovine serum albumin, indocyanine green (ICG), and an oxygen-independent radicals generator (AIPH) for efficient sequential cancer therapy, denoted as BIA NPs. Upon near-infrared irradiation, the photothermal effect generated by ICG will induce rapid decomposition of AIPH to release cytotoxic alkyl radicals, leading to cancer cell death in both normoxic and hypoxic environments. Moreover, such nanosystem provides the highest AIPH loading capacity (14.9%) among all previously reported radical nanogenerators (generally from 5-8%). Additionally, the aggregation-quenched fluorescence of ICG molecules in the NPs can be gradually released and recovered upon irradiation enabling real-time drug release monitoring. More attractively, these BIA NPs exhibit remarkable anticancer effects both in vitro and in vivo, achieving 100% tumor elimination and 100% survival rate among 50 days treatment. These results highlight that this albumin-based nanoplatform is promising for high-performance cancer therapy circumventing hypoxic tumor environment and possessing great potential for future clinical translation.
机译：缺氧的微环境由于阻碍了细胞毒性氧自由基的产生，严重降低了氧依赖性光动力疗法在实体瘤中的治疗效果。在本文中，通过将牛血清白蛋白，吲哚菁绿（ICG）和不依赖氧的自由基产生剂（AIPH）结合在一起，开发了生物相容性纳米颗粒（NP），用于有效的顺序癌症治疗，称为BIA NP。在近红外辐射下，ICG产生的光热效应将诱导AIPH迅速分解，释放出细胞毒性烷基自由基，从而在常氧和低氧环境中导致癌细胞死亡。此外，这种纳米系统在所有先前报道的自由基纳米发生器中提供最高的AIPH负载能力（14.9％）（通常为5-8％）。此外，NPs中ICG分子的聚集猝灭荧光可以逐步释放并在照射后恢复，从而可以进行实时药物释放监测。更有吸引力的是，这些BIA NP在体内和体外均显示出显着的抗癌作用，在50天的治疗中可实现100％的肿瘤消除和100％的存活率。这些结果表明，这种基于白蛋白的纳米平台有望绕过缺氧肿瘤环境进行高性能癌症治疗，并具有巨大的未来临床翻译潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号