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首页> 外文期刊>Advanced Functional Materials >Furin-Controlled Fe_3O_4 Nanoparticle Aggregation and ~(19)F Signal 'Turn-On' for Precise MR Imaging of Tumors
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Furin-Controlled Fe_3O_4 Nanoparticle Aggregation and ~(19)F Signal 'Turn-On' for Precise MR Imaging of Tumors

机译：弗林蛋白酶控制的Fe_3O_4纳米粒子聚集和〜（19）F信号“打开”，用于肿瘤的精确MR成像

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For cancer diagnosis, H-1 magnetic resonance imaging (MRI) is advantageous in sensitivity but lacks selectivity. Endogenous F-19 MRI signal in humans is barely detectable and thus F-19 MRI has very high selectivity. A combination of H-1 and F-19 MRI is ideal for precise tumor imaging but a protease-controlled strategy of simultaneous T-2 H-1 MRI enhancement and F-19 MRI "Turn-On" has not been reported. Here, used is a click condensation reaction to rationally project a dual-functional fluorine probe 4-(trifluoromethyl)benzoic acid (TFMB)-Arg-Val-Arg-Arg-Cys(StBu)-Lys-CBT (1), which is further utilized to functionalize Fe3O4 nanoparticle (IONP) to achieve IONP@1. As such, the IONP aggregation can be activated by furin addition, thereby enhancing the T-2 H-1 MRI signal and switching the F-19 NMR/MRI signal "On". Using this strategy, IONP@1 is successfully applied to detect the activity of the furin enzyme with "Turn-On" F-19 NMR/MRI and T-2 H-1 MRI signals are enhanced. Moreover, IONP@1 is also applied for precise dual-mode (H-1 and F-19) MR imaging of tumors in zebrafish under 14.1 T. The current approach, therefore, provides a feasible and robust means to reconcile the dilemma between selectivity and sensitivity of conventional MRI probes. More importantly, it is envisioned that, by substituting the TFMB moiety in 1 with a perfluorinated compound, this "smart" method could be of potential use for precise H-1 MR and F-19 MR imaging of tumor in mouse or in bigger rodents in near future.
机译：对于癌症诊断，H-1磁共振成像（MRI）在灵敏度方面具有优势，但缺乏选择性。人体中的内源性F-19 MRI信号几乎无法检测到，因此F-19 MRI具有很高的选择性。 H-1和F-19 MRI的组合对于精确的肿瘤成像是理想的，但是尚未报道同时T-2 H-1 MRI增强和F-19 MRI“打开”的蛋白酶控制策略。在这里，使用点击缩合反应合理地投影双功能氟探针4-（三氟甲基）苯甲酸（TFMB）-Arg-Val-Arg-Arg-Cys（StBu）-Lys-CBT（1）进一步用于功能化Fe3O4纳米粒子（IONP）以实现IONP @ 1。这样，可以通过添加弗林蛋白酶来激活IONP聚集，从而增强T-2 H-1 MRI信号并将F-19 NMR / MRI信号切换为“开”。使用此策略，IONP @ 1成功地应用于具有“打开” F-19 NMR / MRI的弗林蛋白酶的活性，并增强了T-2 H-1 MRI信号。此外，IONP @ 1还适用于在14.1 T以下的斑马鱼中肿瘤的精确双模（H-1和F-19）MR成像。因此，当前方法为解决选择性之间的难题提供了一种可行而强大的方法和常规MRI探头的灵敏度。更重要的是，可以预见，通过用全氟化化合物代替1中的TFMB部分，这种“智能”方法可能对小鼠或更大的啮齿动物的肿瘤的精确H-1 MR和F-19 MR成像具有潜在的用途。在不久的将来。

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