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首页> 外文期刊>Advanced Functional Materials >Tunable Chemical and Topographic Patterns Based on Binary Colloidal Crystals (BCCs) to Modulate MC63 Cell Growth
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Tunable Chemical and Topographic Patterns Based on Binary Colloidal Crystals (BCCs) to Modulate MC63 Cell Growth

机译：基于二元胶体晶体（BCC）的可调节化学和地形图案来调节MC63细胞的生长

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摘要

More effective and diversified surface modification strategies are required for materials used in biomedical engineering. Combining surface modification involving bioactive signals or nonfouling polymers with tunable topography has the potential to meet this need. Here, a method is reported to generate bioactive surfaces having tunable topographies based on self-assembled binary colloidal crystals (BCCs), where the colloids are premodified with nonfouling molecules or cell adhesive peptides. The BCCs are fabricated from silica (Si) microspheres and polymer nanospheres. The Si microspheres are either modified with poly(ethylene glycol) (PEG) or with the cell adhesive arginine-glycine-aspartic acid (RGD) peptide prior to BCC fabrication. Four types of BCCs are explored in cell studies using MG63 cells. BCC surfaces coupled with PEG or RGD peptides are found to significantly modulate cell adhesion, spreading, and morphology, which is attributed to the combination of BCC topography and the molecules at the particle surface within the BCC. PEG-modified BCCs are expected to find applications where limited cell adhesion is required, while the RGD-modified BCCs have the potential for enhancing cell growth on medical devices such as bone implants. More advanced cell biology applications such as controlled stem cell differentiation are also anticipated to find use from BCCs.
机译：生物医学工程中使用的材料需要更有效和多样化的表面改性策略。将涉及生物活性信号或不污染聚合物的表面改性与可调整的形貌相结合，有可能满足这一需求。在此，据报道一种基于自组装二元胶体晶体（BCC）生成具有可调整形貌的生物活性表面的方法，其中胶体已被不结垢分子或细胞粘附肽预修饰。 BCC由二氧化硅（Si）微球和聚合物纳米球制成。在制造BCC之前，用聚乙二醇（PEG）或细胞粘附的精氨酸-甘氨酸-天冬氨酸（RGD）肽修饰Si微球。使用MG63细胞在细胞研究中探索了四种类型的BCC。发现与PEG或RGD肽偶联的BCC表面可显着调节细胞粘附，扩散和形态，这归因于BCC形貌与BCC内颗粒表面的分子的结合。 PEG修饰的BCC有望在需要有限的细胞粘附的应用中找到，而RGD修饰的BCC具有增强医疗设备（如骨植入物）上细胞生长的潜力。预计更先进的细胞生物学应用（例如受控干细胞分化）也将从BCC中找到用途。

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  • 来源
    《Advanced Functional Materials》 |2019年第39期|1904262.1-1904262.14|共14页
  • 作者

    Diba Farhana Sharmin; Reynolds Nicholas; Thissen Helmut; Wang Peng-Yuan; Kingshott Peter;

  • 作者单位

    Swinburne Univ Technol Sch Sci Dept Chem & Biotechnol Hawthorn Vic 3122 Australia;

    Swinburne Univ Technol Sch Engn Arc Training Ctr Biodevices Hawthorn Vic 3122 Australia;

    CSIRO Mfg Res Way Clayton Vic 3168 Australia;

    Swinburne Univ Technol Sch Sci Dept Chem & Biotechnol Hawthorn Vic 3122 Australia|CSIRO Mfg Res Way Clayton Vic 3168 Australia|Chinese Acad Sci Shenzhen Inst Adv Technol Inst Biomed & Biotechnol Ctr Human Tissues & Organs Degenerat Shenzhen 518055 Peoples R China;

    Swinburne Univ Technol Sch Sci Dept Chem & Biotechnol Hawthorn Vic 3122 Australia|Swinburne Univ Technol Sch Engn Arc Training Ctr Surface Engn Adv Mat Seam Hawthorn Vic 3122 Australia;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    binary colloidal crystal (BCC) layers; cellular response; PEG; RGD; surface topography;

    机译：二元胶体晶体（BCC）层;细胞反应;PEG;RGD;表面形貌;

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