• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >A Thermal-Reflow-Based Low-Temperature, High-Pressure Sintering of Lyophilized Silk Fibroin for the Fast Fabrication of Biosubstrates
【24h】

A Thermal-Reflow-Based Low-Temperature, High-Pressure Sintering of Lyophilized Silk Fibroin for the Fast Fabrication of Biosubstrates

机译：基于热回流的低温，高压烧结冻干丝素蛋白，用于生物基质的快速制备

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Solid fibroin is a bulk nonporous material that can be prepared with two methods: a liquid-gel-solid transition from a fibroin solution or a sintering procedure starting from silk powder. Both methods have their own disadvantages: the first requires several weeks and the process is size dependent; the second requires high temperatures. To overcome these limitations, a low-temperature sintering procedure based on a thermal-reflow is proposed in this work to produce in fast-fashion monoliths of solid fibroin. Thermal-reflow is a well-known mechanism that takes place when the glass transition temperature of the material is lower than the temperature used to process it. Water plays an important role decreasing the glass transition temperature down to 40 degrees C. For the first time, a thermal reflow is conducted on lyophilized silk fibroin at 40 degrees C, associating to the water addition a high-pressure compression. To optimize the process, a full factorial design of experiment is used. The material is then studied in the crucial phases by digital scanning calorimetry, Fourier-transform infrared spectroscopy, and scanning electron microscopy. Finally, a mechanical characterization and a preliminary in vitro test are conducted.
机译：固体丝蛋白是可以用两种方法制备的块状无孔材料：从丝蛋白溶液的液-凝胶-固相转变或从丝粉开始的烧结过程。两种方法都有其自身的缺点：第一种方法需要几个星期，并且该过程取决于大小。第二个需要高温。为了克服这些限制，在这项工作中提出了一种基于热回流的低温烧结工艺，以生产快速成型的固体丝素整料。热回流是一种众所周知的机制，它发生在材料的玻璃化转变温度低于用于加工的温度时。水起着将玻璃化转变温度降低至40摄氏度的重要作用。这是第一次在40摄氏度下对冻干的丝素蛋白进行热回流，并伴随着水的高压压缩。为了优化过程，使用了完整的因子设计实验。然后在关键阶段通过数字扫描量热法，傅立叶变换红外光谱和扫描电子显微镜对材料进行研究。最后，进行了机械表征和初步的体外测试。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号