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Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis

机译：基于细胞的纳米系统靶向癌症转移的新兴方法

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摘要

Cancer metastasis accounts for the high mortality of cancer-related deaths and the therapy is greatly challenged by the limited drug delivery efficiency. Inspired by the essential role of culprit cancer cells and versatile accessory cells during cancer metastasis, diverse cell-based nanosystems (CBNs) are emerging as attractive and encouraging drug delivery platforms to target cancer metastasis. Herein, the authors focus on the emerging strategies of versatile CBNs that synergistically combine the merit of source cells and nanoparticles for antimetastasis therapy. CBNs are usually comprised of natural nanosized vesicles, cell membrane camouflaged nanoparticles, and bioengineered living cell vehicles. The authors discuss the rationality and advances of various CBNs in targeting different stages of cancer metastasis, including primary tumor, circulating tumor cells (CTCs), and distant metastasis as well as the tumor immune microenvironments (TIM). On this basis, this review provides some feasible perspectives on designing CBNs to enhance the drug delivery efficiency for treating cancer metastasis.
机译：癌症转移导致癌症相关死亡的高死亡率，并且有限的药物递送效率极大地挑战了该疗法。受罪魁祸首癌细胞和多功能辅助细胞在癌症转移过程中的重要作用的启发，多种多样的基于细胞的纳米系统（CBN）成为吸引人的，令人鼓舞的靶向癌症转移的药物递送平台。在本文中，作者集中于通用CBN的新兴策略，这些策略将源细胞和纳米颗粒的优点协同地用于抗转移治疗。 CBN通常由天然纳米大小的囊泡，细胞膜伪装的纳米颗粒和生物工程化的活细胞载体组成。作者讨论了针对各种癌症转移阶段（包括原发性肿瘤，循环肿瘤细胞（CTC）和远处转移以及肿瘤免疫微环境（TIM））的各种CBN的合理性和进展。在此基础上，本综述提供了一些有关设计CBNs以提高药物转移治疗癌症转移效率的可行观点。

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  • 来源
    《Advanced Functional Materials》 |2019年第48期|1903441.1-1903441.36|共36页
  • 作者

    Gong Xiang; Li Jie; Tan Tao; Wang Zhiwan; Wang Hong; Wang Yuqi; Xu Xiaoxuan; Zhang Zhiwen; Li Yaping;

  • 作者单位

    Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res Shanghai 201203 Peoples R China|Chinese Acad Sci Shanghai Inst Mat Med Ctr Pharmaceut Shanghai 201203 Peoples R China|Univ Chinese Acad Sci Sch Pharm Beijing 100049 Peoples R China;

    Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res Shanghai 201203 Peoples R China|Chinese Acad Sci Shanghai Inst Mat Med Ctr Pharmaceut Shanghai 201203 Peoples R China;

    Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res Shanghai 201203 Peoples R China|Chinese Acad Sci Shanghai Inst Mat Med Ctr Pharmaceut Shanghai 201203 Peoples R China|Univ Chinese Acad Sci Sch Pharm Beijing 100049 Peoples R China|Yantai Inst Mat Med Yantai Key Lab Nanomed & Adv Preparat Yantai 264000 Shandong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    cancer metastasis; cell membranes; nanosystems; tumor targeting;

    机译：癌症转移;细胞膜纳米系统肿瘤靶向;

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