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A Melanin-Based Natural Antioxidant Defense Nanosystem for Theranostic Application in Acute Kidney Injury

机译：基于黑色素的天然抗氧化防御纳米系统在急性肾脏损伤中的治疗学应用

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摘要

Acute kidney injury (AKI) is frequently associated with oxidative stress and causes high mortality annually in clinics. Nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for the treatment of AKI. Herein, a novel biomedical use of the endogenous biopolymer melanin as a theranostic natural antioxidant defense nanoplatform for AKI is reported. In this study, ultrasmall Mn2+-chelated melanin (MMP) nanoparticles are easily prepared via a simple coordination and self-assembly strategy, and further incorporated with polyethylene glycol (MMPP). In vitro experiments reveal the ability of MMPP nanoparticles to scavenge multiple toxic reactive oxygen species (ROS) and suppress ROS-induced oxidative stress. Additionally, in vivo results from a murine AKI model demonstrate preferential renal uptake of MMPP nanoparticles and a subsequent robust antioxidative response with negligible side effects according to positron emission tomography/magnetic resonance (PET/MR) bimodal imaging and treatment assessment. These results indicate that the effectiveness of MMPP nanoparticles for treating AKI suggests the potential efficacy of melanin as a natural theranostic antioxidant nanoplatform for AKI, as well as other ROS-related diseases.
机译：急性肾损伤（AKI）通常与氧化应激相关，每年在诊所中导致很高的死亡率。纳米技术介导的抗氧化疗法正在作为一种治疗AKI的新策略而出现。本文中，报道了内源性生物聚合物黑色素作为AKI的天然的天然抗氧化剂防御纳米平台的新型生物医学用途。在这项研究中，可通过简单的配位和自组装策略轻松制备超小Mn2 +螯合的黑色素（MMP）纳米颗粒，并进一步与聚乙二醇（MMPP）结合使用。体外实验揭示了MMPP纳米粒子清除多种有毒活性氧（ROS）并抑制ROS诱导的氧化应激的能力。此外，根据正电子发射断层扫描/磁共振（PET / MR）双峰成像和治疗评估，鼠AKI模型的体内结果证明了MMPP纳米颗粒的优先肾脏摄取和随后的强大的抗氧化反应，且副作用可忽略不计。这些结果表明，MMPP纳米颗粒治疗AKI的有效性表明，黑色素作为AKI以及其他与ROS相关疾病的天然治疗物质抗氧化剂纳米平台的潜在功效。

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  • 来源
    《Advanced Functional Materials》 |2019年第48期|1904833.1-1904833.9|共9页
  • 作者

    Sun Tuanwei; Jiang Dawei; Rosenkrans Zachary T.; Ehlerding Emily B.; Ni Dalong; Qi Chao; Kutyreff Christopher J.; Barnhart Todd E.; Engle Jonathan W.; Huang Peng; Cai Weibo;

  • 作者单位

    Shenzhen Univ Hlth Sci Ctr Sch Biomed Engn Int Canc Ctr Marshall Lab Biomed Engn LET Shenzhen 518060 Guangdong Peoples R China|Univ Wisconsin Dept Radiol Madison WI 53705 USA|Univ Wisconsin Dept Med Phys Madison WI 53705 USA|Shenzhen Univ Coll Optoelect Engn Key Lab Optoelect Devices & Syst Minist Educ & Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

    Shenzhen Univ Hlth Sci Ctr Sch Biomed Engn Int Canc Ctr Marshall Lab Biomed Engn LET Shenzhen 518060 Guangdong Peoples R China|Univ Wisconsin Dept Radiol Madison WI 53705 USA|Univ Wisconsin Dept Med Phys Madison WI 53705 USA;

    Univ Wisconsin Sch Pharm Madison WI 53705 USA;

    Univ Wisconsin Dept Radiol Madison WI 53705 USA|Univ Wisconsin Dept Med Phys Madison WI 53705 USA;

    Shenzhen Univ Hlth Sci Ctr Sch Biomed Engn Int Canc Ctr Marshall Lab Biomed Engn LET Shenzhen 518060 Guangdong Peoples R China;

    Univ Wisconsin Dept Radiol Madison WI 53705 USA|Univ Wisconsin Dept Med Phys Madison WI 53705 USA|Univ Wisconsin Sch Pharm Madison WI 53705 USA|Univ Wisconsin Carbone Canc Ctr Madison WI 53705 USA;

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  • 正文语种 eng
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  • 关键词

    acute kidney injury; melanin nanoparticles; natural antioxidant; reactive oxygen species; theranostics;

    机译：急性肾损伤;黑色素纳米粒子天然抗氧化剂;活性氧治疗学;

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