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首页> 外文期刊>Advanced Functional Materials >Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era
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Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

机译：后抗生素时代到来的抗细菌耐药性发展的技术和策略

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The threats posed by the impending "postantibiotic era" have put forward urgent challenges to be overcome by providing new diagnostic and therapeutic regimes for improved diagnosis and treatment of bacterial infections. Antibiotic resistance and incurable bacterial infections are especially important in a society faced with rapid demographic changes. With very few new antibiotics in the drug development pipeline, not being able to match the pace of antimicrobial resistance evolution, developments within other fields such as materials sciences and medical technologies are required to realize innovative antibacterial approaches. This progress report presents recent advances in especially nanotechnology-based approaches and their concomitant use with complementary antibacterial treatments. Synergistically improved antibacterial activity can be reached by considering novel, promising approaches such as photodynamic and photothermal therapy as well as cold atmospheric pressure treatments as complementary strategies to fight against antibacterial resistance. Moreover, this report describes how these novel technologies can be further improved especially by integration of nanomaterials into the currently applied single modal strategies against bacterial infections.
机译：即将到来的“抗生素后时代”带来的威胁提出了迫切的挑战，需要通过提供新的诊断和治疗方案来改善细菌感染的诊断和治疗。在面对人口快速变化的社会中，抗生素耐药性和无法治愈的细菌感染尤为重要。由于药物开发管道中的新抗生素很少，无法适应抗微生物药物耐药性发展的步伐，因此需要材料科学和医学技术等其他领域的开发来实现创新的抗菌方法。该进展报告介绍了基于纳米技术的方法及其与辅助抗菌治疗同时使用的最新进展。通过考虑新颖的，有希望的方法（例如光动力和光热疗法以及冷大气压疗法）作为对抗细菌耐药性的补充策略，可以达到协同提高的抗菌活性。此外，本报告描述了如何通过将纳米材料整合到当前应用的针对细菌感染的单一模式策略中来进一步改进这些新技术。

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