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首页> 外文期刊>Advanced Functional Materials >Bioinspired Mineral-Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration
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Bioinspired Mineral-Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

机译：生物启发的矿物有机骨粘合剂，​​用于稳定骨折固定和加速骨再生

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摘要

The use of hydrogel-based bone adhesives has the potential to revolutionize the clinical treatment of bone repairs. However, severe deficiencies remain in current products, including cytotoxicity concerns, inappropriate mechanical strength, and poor fixation performance in wet biological environments. Inspired by the unique roles of glue molecules in the robust mechanical strength and fracture resistance of bone, a design strategy is proposed using novel mineral-organic bone adhesives for strong water-resistant fixation and guided bone tissue regeneration. The system leveraged tannic acid (TA) as a phenolic glue molecule to spontaneously co-assemble with silk fibroin (SF) and hydroxyapatite (HA) in order to fabricate the inorganic-organic hybrid hydrogel (named SF@TA@HA). The combination of the strong affinity between SF and TA along with sacrificial coordination bonds between TA and HA significantly improves the toughness and adhesion strength of the hydrogel by increasing the amount of energy dissipation at the nanoscale. This in turn facilitated adequate and stable fixation of bone fracture in wet biological environments. Furthermore, SF@TA@HA promotes the regeneration of bone defects at an early stage in vivo. This work presents a type of bioinspired bone adhesive that is able to provide stable fracture fixation and accelerated bone regeneration during the bone remodeling process.
机译：基于水凝胶的骨粘剂的使用可能会彻底改变骨修复的临床治疗方法。但是，目前的产品仍然存在严重的缺陷，包括细胞毒性问题，不适当的机械强度以及在潮湿生物环境中的固定性能差。受到胶粘剂分子在骨骼的强大机械强度和抗断裂性中的独特作用的启发，提出了一种使用新型矿物-有机骨粘合剂进行强力防水固定和引导骨组织再生的设计策略。该系统利用单宁酸（TA）作为酚醛胶分子，与丝素蛋白（SF）和羟基磷灰石（HA）自发共组装，以制造无机-有机杂化水凝胶（名为SF @ TA @ HA）。 SF和TA之间的强亲和力以及TA和HA之间的牺牲配位键相结合，通过增加纳米级的能量耗散量，显着提高了水凝胶的韧性和粘合强度。反过来，这有助于在潮湿的生物环境中充分，稳定地固定骨折。此外，SF @ TA @ HA在体内早期促进骨缺损的再生。这项工作提出了一种具有生物启发性的骨粘合剂，​​能够在骨重塑过程中提供稳定的骨折固定和加速的骨再生。

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