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Biomaterial-Iinduction of a Transplantable Angiosome

机译：生物材料诱导的可移植血管体

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Creating transplantable vascular networks (angiosomes) that are fed and drained by vessels large enough to be surgically reconnected is key to harnessing the potential of regenerative medicine and advancing reconstructive surgical techniques. Currently, the only way to create a new angiosome is nontrivial and involves pressurizing a vein graft by its surgical attachment to an artery forming an arteriovenous loop (AVL). Material induction of a venous angiosome is reported, by placement of a 3D printed microporous monetite scaffold around a vein and its transplantability is further demonstrated. When the transplanted venosome is cut, it bleeds, illustrating potential reconstructive functionality. The volume of blood vessels generated by biomaterial-induction is as great as by AVL. Direct contact of the material with the vein does not appear to be critical to luminal sprouting, and wrapping the implant in a silicone membrane significantly reduces sprouting. Pilot studies with microporous polymeric scaffolds induce far less vascular invasion. After 4 weeks, monetite scaffolds are extensively vascularized and can be transplanted to an arterial vessel. This report is significant since a lack of tools to control vascular generation is an impediment to the treatment of several conditions that give rise to tissue ischemia and tissue reconstruction.
机译：建立可移植的血管网络（血管体），血管网的供血和引流要大到可以通过外科手术重新连接，这对于利用再生医学的潜力和推进重建性外科手术技术至关重要。当前，创建新的血管小体的唯一方法是不平凡的，并且涉及通过将其外科手术附接到形成动静脉环（AVL）的动脉来加压静脉移植物。据报道，通过在静脉周围放置3D打印的微孔透钙支架，可以诱导静脉血管体，并进一步证明了其可移植性。切下移植的静脉囊时，它会出血，说明潜在的重建功能。生物材料诱导产生的血管体积与AVL一样大。材料与静脉的直接接触对于管腔发芽似乎不是关键，并且将植入物包裹在硅树脂膜中可显着减少发芽。用微孔聚合物支架进行的初步研究诱导的血管侵袭少得多。 4周后，将芒硝支架血管化，可以移植到动脉血管中。该报告意义重大，因为缺乏控制血管生成的工具阻碍了对几种导致组织缺血和组织重建的疾病的治疗。

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