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首页> 外文期刊>Advanced Functional Materials >Nanostructural Control Enables Optimized Photoacoustic-Fluorescence-Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor
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Nanostructural Control Enables Optimized Photoacoustic-Fluorescence-Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor

机译：纳米结构控制可优化脑肿瘤的光声-荧光-磁共振多峰成像和光热疗法。

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摘要

The performance of current multimodal imaging contrast agents is often constrained by the tunability of nanomaterial structural design. Herein, the influence of nanostructure on the overall imaging performance of a composite nanomaterial for multimodal imaging of brain tumors is studied. Newly designed near-infrared molecules (TC1) are encapsulated into nanocomposites with ultrasmall iron oxide nanoparticles (UIONPs), forming stable nanoagents for multimodal imaging and photothermal therapy (PTT). Through a modified nanoprecipitation method, the synthesis of nanocomposites denoted as HALF is realized, in which UIONPs are restricted to half of the nanosphere. Such a unique nanostructure that physically separates TC1 and UIONPs is found with capabilities of mitigating fluorescence quenching, preserving the good performance of photoacoustic imaging, and enhancing the magnetic resonance imaging signals. Decorated with a peptide ligand cRGD for better brain tumor targeting, HALF-cRGD is evaluated both in vitro and in vivo as imaging contrast agents and photothermal therapeutic agents. The good imaging performance and PTT effect of HALF-cRGD in mice models indicate that the rational design and control of nanostructures could optimize multimodal imaging performance using the same components.
机译：当前的多峰成像造影剂的性能通常受到纳米材料结构设计的可调性的限制。在这里，研究了纳米结构对复合纳米材料对脑肿瘤的多峰成像的整体成像性能的影响。新设计的近红外分子（TC1）与超小型氧化铁纳米颗粒（UIONPs）封装成纳米复合材料，形成用于多峰成像和光热疗法（PTT）的稳定纳米剂。通过改进的纳米沉淀方法，实现了以HALF表示的纳米复合材料的合成，其中UIONPs限于纳米球的一半。发现这种物理上分离TC1和UIONP的独特纳米结构具有减轻荧光猝灭，保持光声成像的良好性能以及增强磁共振成像信号的能力。 HALF-cRGD用肽配体cRGD装饰以更好地靶向脑肿瘤，在体外和体内均作为成像造影剂和光热治疗剂进行了评估。 HALF-cRGD在小鼠模型中的良好成像性能和PTT效果表明，合理设计和控制纳米结构可以使用相同的组件优化多峰成像性能。

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