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首页> 外文期刊>Advanced Functional Materials >Self-Powered lontophoretic Transdermal Drug Delivery System Driven and Regulated by Biomechanical Motions
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Self-Powered lontophoretic Transdermal Drug Delivery System Driven and Regulated by Biomechanical Motions

机译：由生物力学运动驱动和调节的自供电离子电渗透皮给药系统

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摘要

Transdermal drug delivery (TDD) systems with feedback control have attracted extensive research and clinical interest owing to their unique advantages of convenience, self-administration, and safety. Here, a self-powered wearable iontophoretic TDD system that can be driven and regulated by the energy harvested from biomechanical motions is proposed for closed-loop motion detection and therapy. A wearable triboelectric nanogenerator (TENG) is used as the motion sensor and energy harvester that can convert biomechanical motions into electricity for iontophoresis without stored-energy power sources, while a hydrogel-based soft patch with side-by-side electrodes is designed to enable noninvasive iontophoretic TDD. Proof-of-concept experiments on pig skin with dyes as model drugs successfully demonstrate the feasibility of the proposed system. This work not only extends the application of TENG in the biomedical field, but may also provide a cost-effective solution for noninvasive, electrically assisted TDD with closed-loop sensing and treatment.
机译：具有反馈控制功能的透皮给药（TDD）系统由于其便捷，自我管理和安全性的独特优势而吸引了广泛的研究和临床兴趣。在此，提出了一种自供电的可穿戴离子电渗疗法TDD系统，该系统可通过从生物力学运动中收集的能量来驱动和调节，以进行闭环运动检测和治疗。可穿戴式摩擦电纳米发生器（TENG）用作运动传感器和能量收集器，可在没有存储能量的电源的情况下将生物力学运动转化为电进行离子电渗疗法的电，而具有并排电极的基于水凝胶的软贴片旨在实现无创离子电渗疗法TDD。以染料为模型药物在猪皮上进行的概念验证实验成功证明了该系统的可行性。这项工作不仅扩展了TENG在生物医学领域的应用，而且还可以为具有闭环感测和治疗的无创，电辅助TDD提供经济高效的解决方案。

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