• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Ag Nanoparticles Cluster with pH-Triggered Reassembly in Targeting Antimicrobial Applications
【24h】

Ag Nanoparticles Cluster with pH-Triggered Reassembly in Targeting Antimicrobial Applications

机译：pH触发重组的Ag纳米粒子簇在靶向抗菌应用中的应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antibacterial efficiency can be effectively improved by applying targeting antibacterial materials and strategies. Herein, the successful synthesis of uniform pH-responsive Ag nanoparticle clusters (AgNCs) is demonstrated, which can collapse and reassemble into nonuniform Ag NPs upon exposure to the acidic microenvironment of bacterial infections. This pH triggered reassembly contributes greatly to the improved antibacterial activities of AgNCs against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). The minimum inhibitory concentration and minimum bactericidal concentration against MRSA are as low as 4 and 32 mu g mL(-1) (which are 8 and 32 mu g mL(-1) for E. coli), respectively. In vivo skin wound healing experiments confirm AgNCs can serve as an effective wound dressing to accelerate the healing of MRSA infection. The development of responsive AgNCs offers new materials and strategies in targeting antibacterial applications.
机译：通过应用靶向抗菌材料和策略可以有效地提高抗菌效率。在本文中，已证明成功合成了均一的pH响应性Ag纳米粒子簇（AgNCs），当暴露于细菌感染的酸性微环境中时，它可以折叠并重新组装成不均一的Ag NPs。此pH触发的重组极大地提高了AgNC对耐甲氧西林金黄色葡萄球菌（MRSA）和大肠杆菌（E. coli）的抗菌活性。对MRSA的最低抑制浓度和最低杀菌浓度分别低至4和32μg mL（-1）（对于大肠杆菌，分别为8和32μg mL（-1））。体内皮肤伤口愈合实验证实，AgNCs可以作为有效的伤口敷料来加速MRSA感染的愈合。响应型AgNC的开发为靶向抗菌应用提供了新的材料和策略。

著录项

  • 来源
    《Advanced Functional Materials》 |2020年第17期|2000511.1-2000511.10|共10页
  • 作者

  • 作者单位

    Hefei Univ Technol Sch Chem & Chem Engn Anhui Prov Key Lab Adv Catalyt Mat & React Engn Key Lab Metab & Regulat Major Dis Anhui Higher Ed Hefei 230009 Peoples R China;

    Hefei Univ Technol Sch Food & Biol Engn Hefei 230009 Peoples R China;

    Univ Sci & Technol China Div Life Sci & Med Affiliated Hosp 1 Cent Lab Med Res Ctr Hefei 230009 Peoples R China;

    Anhui Univ Sch Life Sci Engn Res Ctr Biomed Mat Anhui Key Lab Modern Biomfg 111 Jiulong Rd Hefei 230601 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Ag nanoparticle clusters; pH-responsive; reassembly; targeting antibacterial;

    机译：银纳米粒子簇;pH响应;重新组装;靶向抗菌;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号