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Polymer-Based Porous Microcapsules as Bacterial Traps

机译：聚合物基多孔微胶囊作为细菌陷阱

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摘要

Exposure to live bacteria and accumulation of dead bacteria during bactericidal processes can cause bacterial infectious diseases, implant failure, and antibacterial surface deterioration. Microcapsules with asymmetrically distributed, funnel-shaped pores, which are capable of capturing, retaining, and killing bacteria are developed, offering a solution to bacterial contamination in liquids. It is found that bacterial isolation inside microcapsules is mainly driven by the bacteria's own motility and the microcapsules' geometry. After entry into the microcapsule cavity, the bacteria are stably retained inside. The microcapsules shield surrounding cells from exposure to bacterial toxins, as demonstrated by the coculture of rat embryonic fibroblast cells with microcapsules loaded with live Escherichia coli. The microcapsules can be enhanced with a bactericidal coating covering only the interior cavity. This confines the bacteria-killing process, thereby further increasing biocompatibility. The microcapsules may offer a viable bacteria combatant approach as a potentially advantageous method to eradicate bacterial contamination.
机译：在杀菌过程中暴露于活细菌和死细菌的积累会导致细菌感染性疾病，植入失败以及抗菌表面变质。开发了具有不对称分布，漏斗形孔的微胶囊，该微胶囊能够捕获，保留和杀死细菌，为解决液体中的细菌污染提供了解决方案。发现微胶囊内部的细菌分离主要是由细菌自身的运动性和微胶囊的几何形状驱动的。进入微囊腔后，细菌被稳定地保留在内部。如大鼠胚胎成纤维细胞与载有活大肠埃希氏菌的微胶囊的共培养所证明的那样，微胶囊可保护周围的细胞免受细菌毒素的侵害。可以通过仅覆盖内部空腔的杀菌涂层来增强微胶囊。这限制了细菌杀死过程，从而进一步提高了生物相容性。微胶囊可提供可行的细菌对抗方法，作为消除细菌污染的潜在有利方法。

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  • 来源
    《Advanced Functional Materials》 |2020年第17期|1908855.1-1908855.10|共10页
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  • 作者单位

    Max Planck Inst Med Res Dept Cellular Biophys Jahnstr 29 D-69120 Heidelberg Germany|Heidelberg Univ Inst Phys Chem Dept Biophys Chem Neuenheimer Feld 253 D-69120 Heidelberg Germany;

    Max Planck Inst Med Res Dept Cellular Biophys Jahnstr 29 D-69120 Heidelberg Germany|Heidelberg Univ Inst Phys Chem Dept Biophys Chem Neuenheimer Feld 253 D-69120 Heidelberg Germany|Max Planck Sch Matter Life Jahnstr 29 D-69120 Heidelberg Germany;

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  • 正文语种 eng
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  • 关键词

    antibacterial materials; microfluidics; polymers; porous microcapsules;

    机译：抗菌材料;微流体聚合物多孔微胶囊;

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