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Materials, Mechanics Designs, and Bioresorbable Multisensor Platforms for Pressure Monitoring in the Intracranial Space

机译：用于颅内空间压力监测的材料，力学设计和可生物吸收的多传感器平台

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摘要

Pressures in the intracranial, intraocular, and intravascular spaces are important parameters in assessing patients with a range of conditions, of particular relevance to those recovering from injuries or from surgical procedures. Compared with conventional devices, sensors that disappear by natural processes of bioresorption offer advantages in this context, by eliminating the costs and risks associated with retrieval. A class of bioresorbable pressure sensor that is capable of operational lifetimes as long as several weeks and physical lifetimes as short as several months, as combined metrics that represent improvements over recently reported alternatives, is presented. Key advances include the use of 1) membranes of monocrystalline silicon and blends of natural wax materials to encapsulate the devices across their top surfaces and perimeter edge regions, respectively, 2) mechanical architectures to yield stable operation as the encapsulation materials dissolve and disappear, and 3) additional sensors to detect the onset of penetration of biofluids into the active sensing areas. Studies that involve monitoring of intracranial pressures in rat models over periods of up to 3 weeks demonstrate levels of performance that match those of nonresorbable clinical standards. Many of the concepts reported here have broad applicability to other classes of bioresorbable technologies.
机译：颅内，眼内和血管内空间中的压力是评估患有一系列疾病的患者的重要参数，这些疾病与从受伤或外科手术中康复的患者特别相关。与传统设备相比，通过生物吸收的自然过程消失的传感器在此方面具有优势，因为它消除了与回收相关的成本和风险。提出了一类可生物吸收的压力传感器，该传感器的使用寿命可长达数周，而物理寿命则可短至数月，这是代表比最近报道的替代方法有所改进的组合指标。关键的进展包括：1）使用单晶硅膜和天然蜡材料的混合物，分别在器件的顶表面和周边边缘区域封装器件; 2）机械结构，使封装材料溶解并消失，从而产生稳定的运行;以及3）附加传感器，用于检测生物流体渗透到主动感应区域的开始。涉及在长达3周的时间内监测大鼠模型中颅内压的研究表明，其表现水平可与不可吸收的临床标准相匹配。本文报道的许多概念对其他类别的生物可吸收技术具有广泛的适用性。

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  • 来源
    《Advanced Functional Materials》 |2020年第17期|1910718.1-1910718.15|共15页
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  • 作者单位

    Northwestern Univ Ctr Biointegrated Elect Dept Mech Engn Evanston IL 60208 USA;

    Konkuk Univ Dept Chem Engn Seoul 05029 South Korea;

    Northwestern Univ Dept Mech Engn Evanston IL 60208 USA;

    Washington Univ Sch Med Dept Neurol Surg St Louis MO 63110 USA;

    Seoul Natl Univ Dept Mat Sci & Engn Seoul 08826 South Korea;

    Korea Adv Inst Sci & Technol Dept Mat Sci & Engn Daejeon 34141 South Korea;

    Korea Adv Inst Sci & Technol Dept Chem & Biomol Engn Daejeon 34141 South Korea;

    Northwestern Univ Ctr Biointegrated Elect Evanston IL 60208 USA;

    George Washington Univ Dept Biomed Engn Washington DC 20052 USA;

    Northwestern Univ Dept Civil & Environm Engn Evanston IL 60208 USA|Northwestern Univ Dept Mech Engn Evanston IL 60208 USA|Northwestern Univ Dept Mat Sci & Engn Evanston IL 60208 USA|Northwestern Univ Ctr Biointegrated Elect Evanston IL 60208 USA;

    Northwestern Univ Ctr Biointegrated Elect Evanston IL 60208 USA|Northwestern Univ Dept Mat Sci & Engn Evanston IL 60208 USA|Northwestern Univ Dept Biomed Engn Evanston IL 60208 USA|Northwestern Univ Dept Neurol Surg Evanston IL 60208 USA|Northwestern Univ Dept Chem Mech Engn Evanston IL 60208 USA|Northwestern Univ Dept Elect Engn & Comp Sci Evanston IL 60208 USA|Northwestern Univ Simpson Querrey Inst Evanston IL 60208 USA|Northwestern Univ Feinberg Sch Med Evanston IL 60208 USA;

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  • 正文语种 eng
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  • 关键词

    bioabsorbable electronics; biomedical implants; pressure sensors; transient electronics;

    机译：可生物吸收的电子产品;生物医学植入物;压力传感器;瞬态电子;

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