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Covalent Surface Modification Effects on Single-Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging

机译：共壁表面修饰作用对单壁碳纳米管的定向传感和光学成像。

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摘要

Optical nanoscale technologies often implement covalent or noncovalent strategies for the modification of nanoparticles, whereby both functionalizations are leveraged for multimodal applications but can affect the intrinsic fluorescence of nanoparticles. Specifically, single-walled carbon nanotubes (SWCNTs) can enable real-time imaging and cellular delivery; however, the introduction of covalent SWCNT sidewall functionalizations often attenuates SWCNT fluorescence. Recent advances in SWCNT covalent functionalization chemistries preserve the SWCNT's pristine graphitic lattice and intrinsic fluorescence, and here, such covalently functionalized SWCNTs maintain intrinsic fluorescence-based molecular recognition of neurotransmitter and protein analytes. The covalently modified SWCNT nanosensor preserves its fluorescence response towards its analyte for certain nanosensors, presumably dependent on the intermolecular interactions between SWCNTs or the steric hindrance introduced by the covalent functionalization that hinders noncovalent interactions with the SWCNT surface. These SWCNT nanosensors are further functionalized via their covalent handles with a targeting ligand, biotin, to self-assemble on passivated microscopy slides, and these dual-functionalized SWCNT materials are explored for future use in multiplexed sensing and imaging applications.
机译：光学纳米级技术通常实施共价或非共价策略来修饰纳米颗粒，从而两种功能化都可用于多峰应用，但会影响纳米颗粒的固有荧光。具体而言，单壁碳纳米管（SWCNT）可以实现实时成像和细胞递送。但是，共价SWCNT侧壁功能化的引入通常会减弱SWCNT荧光。 SWCNT共价官能化化学的最新进展保留了SWCNT的原始石墨晶格和固有荧光，在这里，这种共价官能化的SWCNT保持了神经递质和蛋白质分析物基于固有荧光的分子识别。共价修饰的SWCNT纳米传感器对于某些纳米传感器保留了其对分析物的荧光响应，大概取决于SWCNT之间的分子间相互作用或由共价官能化引入的位阻，该位阻阻碍了与SWCNT表面的非共价相互作用。这些SWCNT纳米传感器通过它们的共价键与靶向配体生物素进一步功能化，以在钝化显微镜载玻片上自组装，并且探索了这些双重功能化的SWCNT材料，以备将来在多重传感和成像应用中使用。

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  • 来源
    《Advanced Functional Materials》 |2020年第17期|1910556.1-1910556.8|共8页
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  • 作者单位

    Univ Calif Berkeley Dept Chem & Biomol Engn Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Chem & Biomol Engn Berkeley CA 94720 USA|Chan Zuckerberg Biohub San Francisco CA 94158 USA|Univ Calif Berkeley Calif Inst Quantitat Biosci Qb3 Berkeley CA 94720 USA;

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  • 正文语种 eng
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  • 关键词

    biosensing; fluorescence; imaging; single-walled carbon nanotubes; surface functionalization;

    机译：生物传感荧光成像单壁碳纳米管;表面功能化;

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