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首页> 外文期刊>Advanced Functional Materials >Photosynthetic Biohybrid Nanoswimmers System to Alleviate Tumor Hypoxia for FL/PA/MR Imaging-Guided Enhanced Radio-Photodynamic Synergetic Therapy
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Photosynthetic Biohybrid Nanoswimmers System to Alleviate Tumor Hypoxia for FL/PA/MR Imaging-Guided Enhanced Radio-Photodynamic Synergetic Therapy

机译：光合生物杂交纳米游泳系统，以减轻肿瘤缺氧的FL / PA / MR成像引导的增强的放射光动力协同治疗。

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摘要

Biohybrid microswimmers have recently shown to be able to actively perform in targeted delivery and in vitro biomedical applications. However, more envisioned functionalities of the microswimmers aimed at in vivo treatments are still challenging. A photosynthetic biohybrid nanoswimmers system (PBNs), magnetic engineered bacteria-Spirulina platensis, is utilized for tumor-targeted imaging and therapy. The engineered PBNs is fabricated by superparamagnetic magnetite (Fe3O4 NPs) via a dip-coating process, enabling its tumor targeting ability and magnetic resonance imaging property after intravenous injection. It is found that the PBNs can be used as oxygenerator for in situ O-2 generations in hypoxic solid tumors through photosynthesis, modulating the tumor microenvironment (TME), thus improving the effectiveness of radiotherapy (RT). Furthermore, the innate chlorophyll released from the RT-treated PBNs, as a photosensitizer, can produce cytotoxic reactive oxygen species under laser irradiation to achieve photodynamic therapy. Excellent tumor inhibition can be realized by the combined multimodal therapies. The PBNs also possesses capacities of chlorophyll-based fluorescence and photoacoustic imaging, which can monitor the tumor therapy and tumor TME environment. These intriguing properties of the PBNs provide a promising microrobotic platform for TME hypoxic modulation and cancer theranostic applications.
机译：最近，生物杂交微泳器能够在靶向递送和体外生物医学应用中积极发挥作用。然而，针对体内治疗的微游泳器的更多预期功能仍然具有挑战性。利用光合生物杂交纳米游泳系统（PBNs），磁性工程菌-螺旋藻（Spirulina platensis），将其用于肿瘤靶向成像和治疗。 PBN是由超顺磁性磁铁矿（Fe3O4 NPs）通过浸涂工艺制造的，具有静脉注射后的肿瘤靶向能力和磁共振成像特性。已经发现，PBN可以通过光合作用在缺氧性实体瘤中作为O-2代的原位氧合剂，调节肿瘤微环境（TME），从而提高放射疗法（RT）的有效性。此外，从RT处理的PBN中释放的先天叶绿素作为光敏剂，可以在激光照射下产生细胞毒性的活性氧，从而实现光动力疗法。联合的多模式疗法可以实现出色的肿瘤抑制作用。 PBN还具有基于叶绿素的荧光和光声成像功能，可以监视肿瘤治疗和肿瘤TME环境。 PBN的这些有趣特性为TME低氧调节和癌症治疗治疗应用提供了有希望的微机器人平台。

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  • 来源
    《Advanced Functional Materials》 |2020年第17期|1910395.1-1910395.11|共11页
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    Zhejiang Univ Eye Ctr Affiliated Hosp 2 Sch Med Hangzhou 310058 Peoples R China|Zhejiang Univ Lab Canc Prevent & Intervent MOE Affiliated Hosp 2 Sch Med Hangzhou 310058 Peoples R China|Zhejiang Univ Inst Translat Med Hangzhou 310058 Peoples R China;

    Zhejiang Univ Inst Translat Med Hangzhou 310058 Peoples R China;

    Zhejiang Univ Eye Ctr Affiliated Hosp 2 Sch Med Hangzhou 310058 Peoples R China|Zhejiang Univ Lab Canc Prevent & Intervent MOE Affiliated Hosp 2 Sch Med Hangzhou 310058 Peoples R China|Zhejiang Univ Inst Translat Med Hangzhou 310058 Peoples R China|Zhejiang Univ State Key Lab Modern Opt Instrumentat Hangzhou 310058 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    cancer therapy; microswimmers; photosynthetic bacteria; spirulina platensis; tumor hypoxia;

    机译：癌症治疗;微泳光合细菌;螺旋藻肿瘤缺氧;

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