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Red-Blood-Cell Waveguide as a Living Biosensor and Micromotor

机译：红血细胞波导作为生物传感器和微电机

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摘要

With great potential in intelligent sensing and actuating systems, biosensors and micromotors are expected to be powerful instruments for early diagnosis and drug delivery in precision medicine. However, it is difficult to ensure the synthetic biosensors and micromotors are compatible with biosystems because of their exogenous building blocks. Biocompatible biosensors and micromotors assembled are reported from living red blood cells (RBCs) optically bound into a waveguide using fiber probes. By monitoring light propagation of the RBC waveguide, the pH of blood solution is detected in real time with an accuracy of 0.05. This can be used for the diagnosis of pH-related disorders of the blood. After diagnosis, optical torque is exerted on the RBC waveguide, allowing it to rotate as a micromotor and transport microparticles to a target region. The RBC waveguide is then constructed inside zebrafish blood vessels to validate in vivo application. The living biosensors and micromotors are expected to provide a "smart" platform for precise biosensing, medical analysis, and drug delivery.
机译：生物传感器和微电机在智能传感和执行系统中具有巨大潜力，有望成为精密医学中早期诊断和药物输送的有力工具。但是，由于合成生物传感器和微电机的外在构建模块，因此很难确保它们与生物系统兼容。据报道，通过使用纤维探针将生物相容的生物传感器和微型马达组装成活体红细胞（RBC），这些红细胞以光学方式绑定到波导中。通过监视RBC波导的光传播，可以以0.05的精度实时检测血液溶液的pH。这可用于诊断与血液pH相关的疾病。诊断后，光扭矩施加在RBC波导上，使其作为微型电动机旋转并将微粒传输到目标区域。然后在斑马鱼血管内构建RBC波导，以验证体内应用。活体生物传感器和微电机有望为精确的生物传感，医学分析和药物输送提供一个“智能”平台。

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