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Pinecone-Inspired Nanoarchitectured Smart Microcages Enable Nano/Microparticle Drug Delivery

机译：Pinecone启发纳米建筑智能种子使纳米/微粒药物递送

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摘要

Drug delivery plays a vital role in medicine and health, but the on-demand delivery of large-sized drugs using stimuli-triggered carriers is extremely challenging. Most present capsules consist of polymeric dense shells with nanosized pores (10 nm), thus typically lack permeability for nano/microparticle drugs. Here, a pinecone-inspired smart microcage with open network shells, assembled from cellulose nanofibrils (CNFs), is reported for nano/microparticle drug delivery. The approach allows the nanoarchitectured, functionalized CNFs to assemble into mechanically robust, haystack-like network shells with tunable large-through pores and polypeptide-anchored points on a large scale. Such open network shells can intelligently open/close triggered by lesion stimuli, making the therapy "always on-demand." The resulting pinecone-inspired microcages exhibit integrated properties of superior structural stability, superhydrophilicity, and pH-triggered, smart across-shell transport of emerging antimicrobial silver nanoparticles and bioactive silicate nanoplatelets (sizes of 100 nm), which enable both extraordinary anti-infection and bone regeneration. This work provides new insights into the design and development of multifunctional encapsulation and delivery carriers for medical and environmental applications.
机译：药物交付在医学和健康中起着至关重要的作用，但使用刺激触发的载体的大型药物的按需交付极为挑战。大多数本发明的胶囊由聚合物致密壳组成，具有纳米孔（<10nm），因此通常缺乏用于纳米/微粒药物的渗透性。这里，据报道，从纤维素纳米纤维（CNFS）组装的PineCone启发的智能微量料，用于纳米/微粒药物递送。该方法允许纳米建筑功能化的CNF组装成机械稳健的干草状网络壳，其具有大孔的可调大孔和大型锚定点。这种开放的网络壳可以智能地打开/关闭由病变刺激触发，使疗法成为“始终按需”。得到的PineCone启发的显微片表现出卓越的结构稳定性，超级水性和pH-触发的综合性质，智能的抗微生物纳米颗粒和生物活性硅酸盐纳米粒子（尺寸> 100nm），这使得既有非凡的杀虫剂和骨再生。这项工作为医疗和环境应用的多功能封装和交付载体的设计和开发提供了新的见解。

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  • 来源
    《Advanced Functional Materials》 |2020年第28期|2002434.1-2002434.10|共10页
  • 作者

    Zhang Shichao; Zhou Sheng; Liu Hui; Xing Malcolm; Ding Bin; Li Bingyun;

  • 作者单位

    West Virginia Univ Dept Orthoped Sch Med Morgantown WV 26506 USA;

    West Virginia Univ Dept Orthoped Sch Med Morgantown WV 26506 USA;

    Donghua Univ Innovat Ctr Text Sci & Technol Shanghai 200051 Peoples R China;

    Univ Manitoba Dept Mech Engn Winnipeg MB R3T 2N2 Canada|Childrens Hosp Res Inst Manitoba Winnipeg MB R3E 3P4 Canada;

    Donghua Univ Innovat Ctr Text Sci & Technol Shanghai 200051 Peoples R China;

    West Virginia Univ Dept Orthoped Sch Med Morgantown WV 26506 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antimicrobial activity; bone regeneration; drug delivery; microcage; self-assembly;

    机译：抗微生物活性;骨再生;药物递送;显微量;自我组装;

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