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Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

机译：Nanomedicine在神经变性障碍治疗中的最新进展

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Recent times have witnessed an upsurge in the incidence of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and amyotrophic lateral sclerosis. The treatment of the same remains a daunting challenge due to the limited access of therapeutic moieties across the blood-brain barrier. Engineered nanoparticles with a size less than 100 nm provide multifunctional abilities for solving these biomedical and pharmacological issues due to their unique physico-chemical properties along with capability to cross the blood-brain barrier. Needless to mention, there is a scarcity of review articles summarizing recent developments of various nanomaterials including liposomes, polymeric nanoparticles, metal nanoparticles, and bio-nanoparticles toward the therapeutic and theranostics applications for various neurodegenerative disorders. Here, a broad spectrum of nanomedicinal approaches to eradicate neurodegenerative disorders is provided, along with a brief account of neuroprotection and neuronal tissue regeneration, current clinical status, issues related to safety, toxicity, challenges, and future outlook.
机译：近期目睹了神经退行性疾病的发病率，如阿尔茨海默病，帕金森病，亨廷顿疾病，朊病毒疾病和肌萎缩侧面硬化症等发病率。由于血脑屏障跨越血脑屏障的治疗部分有限，同样的处理仍然是令人生畏的挑战。尺寸小于100nm的工程纳米颗粒提供了多功能能力，用于解决这些生物医学和药理学问题，因为它们独特的物理化学性质以及穿过血脑屏障的能力。毋庸置疑，稀缺的审查制品总结了各种纳米材料的最新发展，包括脂质体，聚合物纳米颗粒，金属纳米颗粒和生物纳米颗粒，朝向治疗性和治疗性的各种神经变性障碍的应用。这里，提供了一种广泛的纳米封闭方法来消除神经变性障碍的方法，以及神经保护和神经元组织再生，当前临床状况，与安全，毒性，挑战和未来前景有关的问题。

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