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Vanadium Core-Shell Nanorods Inspect Metabolic Changes of Diabetic Retinopathy

机译：钒芯壳纳米棒检查糖尿病视网膜病变的代谢变化

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摘要

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and ranks as the fifth leading cause of visual impairment, but an understanding of DR development has been hampered by the lack of an efficient metabolomic tool. Herein, vanadium core-shell nanorods are developed for metabolic fingerprinting to probe molecular variation in DR. First, a series of vanadium core-shells are constructed with different elemental composition and structural parameters, using silica nanorods to support vanadium oxide. The plasma metabolic fingerprints (MFs) are extracted by the optimized vanadium core-shell nanorod-assisted laser desorption/ionization mass spectrometry, by analyzing 500 nL of native plasma in seconds. As a result, DR patients are differentiated from non DR controls with a sensitivity of 94% and specificity of 90% using a classification model built on the plasma MFs. Furthermore, DR progression is monitored by a panel of plasma metabolic signatures with gradual changes. This work provides an advanced molecular tool for the metabolomic characterization of DR and may guide the clinical decision making in DR for personalized medicine in the future.
机译：糖尿病视网膜病变（DR）是糖尿病最常见的微血管并发症，作为视力障碍的第五个主要原因，但缺乏有效的代原工具，对博士的发展受到阻碍。在此，开发钒核 - 壳纳米棒用于代谢指纹识别，以探测DR的分子变化。首先，使用硅纳米芯片用不同的元素组成和结构参数构建一系列钒核 - 壳，以支持氧化钒。通过在几秒钟内分析500nl的天然血浆，通过优化的钒核 - 壳纳米棒纳米棒辅助激光解吸/电离质谱法提取等离子体代谢指纹（MFS）。结果，博士患者使用在等离子体MF上的分类模型与INVER DR控制的敏感性为94％和90％的特异性。此外，通过逐渐变化的等离子体代谢签名小组监测DR进展。这项工作为博士的代谢组织提供了先进的分子工具，并可在未来指导博士中的临床决策。

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  • 来源
    《Advanced Functional Materials》 |2020年第35期|2002791.1-2002791.10|共10页
  • 作者

    Vedarethinam Vadanasundari; Huang Lin; Zhang Minchun; Su Haiyang; Hu Huiqian; Xia Hanping; Liu Yu; Wu Beirui; Wan Xu; Shen Jie; Xu Lin; Liu Wei; Ma Jing; Qian Kun;

  • 作者单位

    Shanghai Jiao Tong Univ State Key Lab Oncogenes & Related Genes Renji Hosp Div Cardiol Sch Med Shanghai Canc Inst 160 Pujian Rd Shanghai 200127 Peoples R China|Shanghai Jiao Tong Univ Sch Biomed Engn Shanghai 200030 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes & Related Genes Renji Hosp Div Cardiol Sch Med Shanghai Canc Inst 160 Pujian Rd Shanghai 200127 Peoples R China|Shanghai Jiao Tong Univ Sch Biomed Engn Shanghai 200030 Peoples R China;

    Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Endocrinol & Metab Shanghai 200127 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes & Related Genes Renji Hosp Div Cardiol Sch Med Shanghai Canc Inst 160 Pujian Rd Shanghai 200127 Peoples R China|Shanghai Jiao Tong Univ Sch Biomed Engn Shanghai 200030 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes & Related Genes Renji Hosp Div Cardiol Sch Med Shanghai Canc Inst 160 Pujian Rd Shanghai 200127 Peoples R China|Shanghai Jiao Tong Univ Sch Biomed Engn Shanghai 200030 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes & Related Genes Renji Hosp Div Cardiol Sch Med Shanghai Canc Inst 160 Pujian Rd Shanghai 200127 Peoples R China|Shanghai Jiao Tong Univ Sch Biomed Engn Shanghai 200030 Peoples R China;

    Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Endocrinol & Metab South Campus Shanghai 201112 Peoples R China;

    Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Endocrinol & Metab South Campus Shanghai 201112 Peoples R China;

    Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Pharm South Campus Shanghai 201112 Peoples R China;

    Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Ophthalmol South Campus Shanghai 201112 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Engn Ctr Visual Sci & Photomed Sch Med Shanghai Key Lab Ocular Fundus Dis Shanghai Gen H Natl Clin Res Ctr Eye Dis Shanghai Peoples Hosp 1 Shanghai 200080 Peoples R China|Shanghai Jiao Tong Univ Sch Med Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Endocrinol & Metab Shanghai 200127 Peoples R China;

    Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Endocrinol & Metab Shanghai 200127 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes & Related Genes Renji Hosp Div Cardiol Sch Med Shanghai Canc Inst 160 Pujian Rd Shanghai 200127 Peoples R China|Shanghai Jiao Tong Univ Sch Biomed Engn Shanghai 200030 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    diabetic retinopathy; diagnostics; metabolic fingerprints; progression evaluation; vanadium core-shell nanorods;

    机译：糖尿病视网膜病;诊断;代谢指纹;进展评估;钒芯壳纳米棒;

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