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首页> 外文期刊>Advanced Functional Materials >Remote Manipulation of Slidable Nano-Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages
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Remote Manipulation of Slidable Nano-Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages

机译：可滑动纳米配体开关的远程操纵调节巨噬细胞的粘附性和再生极化

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摘要

The development of materials capable of varying macroscale ligand distributions can emulate an extracellular matrix (ECM) remodeling and regulate the adhesion and polarization of macrophages. In this report, negatively charged slidable nano-ligands are assembled and then conjugated to a positively charged substrate via electrostatic interaction. The negatively charged slidable nano-ligands are prepared by coating magnetic nanoparticles with a polymer linker and negatively charged RGD ligand. The nano-ligand sliding is characterized under an external magnetic field, which spatiotemporally alters macroscale ligand density. To the best of knowledge, this is the first demonstration that magnetic maipulation of the macroscale ligand density inhibits inflammatory M1 phenotype but stimulates the adhesion and regenerative M2 phenotype of host macrophages. Furthermore, it is elucidated that the magnetic attraction of the slidable nano-ligand facilitates the assembly of adhesion structures in macrophages, thereby stimulating their regenerative M2 phenotype. The design of ECM-emulating materials that allow remote, spatiotemporal, and reversible controllability of macroscale ligand density provides an appealing strategy in the spatiotemporal regulation of immunomodulatory tissue-regenerative responses to implants in vivo.
机译：能够改变Macroscale配体分布的材料的发展可以模拟细胞外基质（ECM）重塑并调节巨噬细胞的粘附性和极化。在本报告中，组装带负电的可滑动纳米配体，然后通过静电相互作用将其与带正电荷的基底缀合。通过用聚合物接头涂覆磁性纳米颗粒和带负电荷的RGD配体来制备带负电的可滑动的纳米配体。纳米配体滑动的特征在于外部磁场，该磁性造型改变了宏观的配体密度。据最知识，这是第一次演示，即麦克雷粒子配体密度的磁性织物抑制炎症M1表型，但刺激宿主巨噬细胞的粘附和再生M2表型。此外，阐明可滑动纳米配体的磁吸引力有助于组装在巨噬细胞中的粘合结构，从而刺激其再生M2表型。 ECM仿真材料的设计，允许遥远，时空和可逆可控性的Macroscale配体密度提供了一种吸引力的免疫调节，在体内植入物的免疫调节组织再生反应时的吸引力策略。

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  • 来源
    《Advanced Functional Materials》 |2020年第35期|2001446.1-2001446.13|共13页
  • 作者

    Choi Hyojun; Bae Gunhyu; Khatua Chandra; Min Sunhong; Jung Hee Joon; Li Na; Jun Indong; Liu Hui-Wen; Cho Youngkyu; Na Kyu-Hwan; Ko Minji; Shin Hongchul; Kim Yoon Hyuck; Chung Seok; Song Jae-Jun; Dravid Vinayak P.; Kang Heemin;

  • 作者单位

    Korea Univ Dept Mat Sci & Engn Seoul 02841 South Korea;

    Korea Univ Dept Mat Sci & Engn Seoul 02841 South Korea;

    Korea Univ Dept Mat Sci & Engn Seoul 02841 South Korea;

    Korea Univ Dept Mat Sci & Engn Seoul 02841 South Korea;

    Northwestern Univ Dept Mat Sci & Engn Evanston IL 60208 USA|Int Inst Nanotechnol Evanston IL 60208 USA|Northwestern Univ NUANCE Ctr Evanston IL 60208 USA;

    Korea Univ Dept Otorhinolaryngol Head & Neck Surg Coll Med Seoul 08308 South Korea;

    Korea Univ Dept Otorhinolaryngol Head & Neck Surg Coll Med Seoul 08308 South Korea;

    Korea Univ Sch Mech Engn Seoul 02841 South Korea;

    Korea Univ Sch Mech Engn Seoul 02841 South Korea;

    Korea Univ Sch Mech Engn Seoul 02841 South Korea;

    Korea Univ Dept Mat Sci & Engn Seoul 02841 South Korea;

    Korea Univ Dept Biotechnol Seoul 02841 South Korea;

    Korea Univ KU KIST Grad Sch Converging Sci & Technol Seoul 02841 South Korea;

    Korea Univ Sch Mech Engn Seoul 02841 South Korea|Korea Univ Dept Biomicrosyst Technol Seoul 02841 South Korea;

    Korea Univ Dept Otorhinolaryngol Head & Neck Surg Coll Med Seoul 08308 South Korea;

    Northwestern Univ Dept Mat Sci & Engn Evanston IL 60208 USA|Int Inst Nanotechnol Evanston IL 60208 USA|Northwestern Univ NUANCE Ctr Evanston IL 60208 USA;

    Korea Univ Dept Mat Sci & Engn Seoul 02841 South Korea|Korea Univ Dept Biomicrosyst Technol Seoul 02841 South Korea;

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  • 正文语种 eng
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  • 关键词

    macrophage adhesion; macrophage polarization; macroscale ligand manipulation; reversible ligand sliding; slidable nano-ligand;

    机译：巨噬细胞粘附;巨噬细胞极化;Macroscale配体操纵;可逆配体滑动;可滑动的纳米配体;

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