• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration
【24h】

Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

机译：用MSC分泌的细胞外囊泡官能化的生物材料和组织再生的可溶因子

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to their secreted factors, including extracellular vesicles (EVs) and soluble factors. The potential of employing the MSC secretome as an alternative acellular approach to cell therapy is being investigated in various tissue injury indications, but EVs administered via bolus injections are rapidly sequestered and cleared. However, biomaterials offer delivery platforms to enhance EV retention rates and healing efficacy. This review highlights the mechanisms underpinning the therapeutic effects of MSC-EVs and soluble factors as effectors of immunomodulation and tissue regeneration, conferred primarily via their nucleic acid and protein contents. Discussed is how manipulating the cell culture microenvironment or genetic modification of MSCs can further augment the potency of their secretions. The most recent advances in the development of EV-functionalized biomaterials that mediate enhanced angiogenesis and cell survival, while attenuating inflammation and fibrosis, are presented. Finally, some technical challenges to be considered for the clinical translation of biomaterials carrying MSC-secreted bioactive cargo are discussed.
机译：间充质基质细胞（MSC）移植的治疗益处归因于其分泌因子，包括细胞外囊泡（EVS）和可溶性因子。在各种组织损伤适应症中研究了使用MSC沉淀作为替代的细胞疗法的替代细胞疗法的潜力，但通过推注注射施用的EVS迅速螯合并清除。然而，生物材料提供交付平台，以提高EV保留率和愈合效果。本综述突出了支撑MSC-EVS和可溶性因子作为免疫调节和组织再生的效果的机制，主要通过它们的核酸和蛋白质含量赋予。讨论的是操纵细胞培养微环境或MSC的遗传修饰如何进一步增加分泌物的效力。提出了介绍增强血管生成和细胞存活的EV官能化生物材料的最新进展，同时衰减炎症和纤维化。最后，讨论了携带MSC分泌的生物活性货物的生物材料临床翻译的一些技术挑战。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号