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Head-Mounted Devices for Noninvasive Cancer Imaging and Intraoperative Image-Guided Surgery

机译：用于非侵入性癌症成像和术中图像引导手术的头戴式设备

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Medical imaging methods have improved the detection of human diseases with increasing accuracy. The ability to probe molecular processes noninvasively or using tissue-selective imaging agents and nanoparticles has made it possible to localize, identify the stage, and determine the functional status of pathological lesions. The challenges in detecting cancer particularly have driven the development of diverse imaging technologies. While earlier cancer imaging methods enabled preoperative evaluation, the need to track and visualize cancer location in the operating room itself has ushered in new systems capable of providing concurrent images of cancer during surgery. Intraoperative use of conventional clinical imaging modalities is often limited by bulky hardware design, prohibitive cost, lack of real-time image display, and compatibility with conventional hardware interfaces. For these reasons, focus on fluorescence-guided surgery (FGS) devices has increased to take advantage of real-time, high-resolution, functional imaging with hardware that has become increasingly amenable to miniaturization. In particular, the adaptation of wearable devices for FGS presents hands-free capability for optimal navigation during cancer surgery. The evolution of head-mounted devices in the operating room and adaptation for FGS is highlighted. Key challenges to wide clinical adoption of this imaging platform are identified and potential future directions are suggested.
机译：医学成像方法随着准确度的提高而改善了人类疾病的检测。无侵染或使用组织选择性成像剂和纳米颗粒探测分子过程的能力使得可以定位，鉴定阶段，并确定病理病变的功能状态。检测癌症的挑战尤其驱使了多样化的成像技术的发展。虽然早期的癌症成像方法使术前评估，但需要跟踪和可视化操作室本身的癌症位置已经迎来了在手术期间能够提供癌症并发图像的新系统。常规临床成像模型的术中使用通常受到庞大的硬件设计，欠高成本，缺乏实时图像显示的限制，以及与传统硬件接口的兼容性。由于这些原因，专注于荧光引导的手术（FGS）器件增加了利用实时，高分辨率功能成像，其硬件变得越来越可享受小型化。特别地，用于FGS的可穿戴设备的适应在癌症手术期间为最佳导航提供免提能力。突出显示手术室中的头戴式设备的演变和FGS的适配。确定了这种成像平台的广泛临床采用的关键挑战，并提出了潜在的未来方向。

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