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Nanocarrier-Mediated Cytosolic Delivery of Biopharmaceuticals

机译：纳米载波介导的生物制药的细胞溶质递送

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摘要

Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown promise in the rapidly expanding pharmaceutical market due to their high specificity and potency. However, the delivery of these biologics is hindered by various physiological barriers, owing primarily to the poor cell membrane permeability, low stability, and increased size of biologic agents. Since many biological drugs are intended to function by interacting with intracellular targets, their delivery to intracellular targets is of high relevance. In this review, the authors summarize and discuss the use of nanocarriers for intracellular delivery of biopharmaceuticals via endosomal escape and, especially, the routes of direct cytosolic delivery by means including the caveolae-mediated pathway, contact release, intermembrane transfer, membrane fusion, direct translocation, and membrane disruption. Strategies with high potential for translation are highlighted. Finally, the authors conclude with the clinical translation of promising carriers and future perspectives.
机译：生物制药已经出现在疾病治疗中起着至关重要的作用，并且由于其高特异性和效力，在快速扩大的药物市场中表现出承诺。然而，这些生物制剂的递送受到各种生理屏障的阻碍，主要是较差的细胞膜渗透性，低稳定性和生物制剂的尺寸增加。由于许多生物学药物旨在通过与细胞内靶标相互作用来起作用，因此它们向细胞内靶标的输送具有高相关性。在本次综述中，作者总结和讨论了纳米载体通过内体逃逸使用纳米载体用于细胞内递送生物制药，特别是通过致直接细胞溶质递送的途径，包括Caveolae介导的途径，接触释放，内膜转移，膜融合，直接易位和膜中断。突出了翻译潜力高的策略。最后，作者随着有前途的承运人和未来观点的临床翻译而言。

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  • 来源
    《Advanced Functional Materials》 |2020年第37期|1910566.1-1910566.22|共22页
  • 作者

    He Wei; Xing Xuyang; Wang Xiaoling; Wu Debra; Wu Wei; Guo Junling; Mitragotri Samir;

  • 作者单位

    China Pharmaceut Univ Sch Pharm Dept Pharmaceut Nanjing 210009 Peoples R China;

    China Pharmaceut Univ Sch Pharm Dept Pharmaceut Nanjing 210009 Peoples R China;

    Sichuan Univ Sch Biomass Sci & Engn Chengdu 610065 Peoples R China;

    Harvard Univ John A Paulson Sch Engn & Appl Sci Cambridge MA 02138 USA|Harvard Univ Wyss Inst Biol Inspired Engn Boston MA 02115 USA;

    Fudan Univ Sch Pharm Minist Educ China Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China;

    Sichuan Univ Sch Biomass Sci & Engn Chengdu 610065 Peoples R China|Harvard Univ Wyss Inst Biol Inspired Engn Boston MA 02115 USA;

    Harvard Univ John A Paulson Sch Engn & Appl Sci Cambridge MA 02138 USA|Harvard Univ Wyss Inst Biol Inspired Engn Boston MA 02115 USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    biopharmaceuticals; cytosolic delivery; endosomal escape; intracellular delivery; nanocarriers;

    机译：生物药物;细胞溶质递送;内体逃逸;细胞内递送;纳米载波;

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