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Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium

机译：导电熔体电扫描贴片与人心肌机械各向异性相匹配

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Cardiac patches represent a promising strategy for the treatment of myocardial infarction (MI). Here, an electroconductive cardiac patch that conforms to the mechanics of human myocardium is fabricated. By melt electrospinning writing (MEW), it is possible to fabricate an auxetic patch that can overcome the limited range of elasticity seen in conventional square patch designs. The auxetic patches can accommodate the strains and stresses exhibited by the human myocardium during diastole and systole. It is shown that the geometry of the auxetic patches can be fine-tuned to reflect anisotropic mechanical properties. The anisotropic ratio of effective stiffness (E-1/E-2) of the auxetic patches agrees with the directionally-dependent mechanics of the heart. Furthermore, in situ polymerization of doped-polypyrrole (PPy) on the auxetic patches confers electroconductive properties close to those reported of human myocardium. This approach demonstrates the potential use of a rational design of PPy-coated patches for their use as cardiac patches.
机译：心脏补丁代表了治疗心肌梗死（MI）的有希望的策略。这里，制造了符合人心肌机制的导电心脏贴片。通过熔化的静电纺丝书写（MEW），可以制造扶手贴片，其可以克服传统方形贴片设计中看到的有限的弹性范围。扶手贴片可以容纳人心肌在舒张和收缩过程中呈现的菌株和应力。结果表明，可以微调辅助贴片的几何形状以反映各向异性机械性能。扶手贴片的有效刚度（E-1 / E-2）的各向异性比例与心脏的定向依赖性机制同意。此外，在辅助斑块上的掺杂聚吡咯（PPY）的原位聚合赋予接近人心肌报告的导电性能。这种方法表明，潜在使用PPY涂层斑块的理性设计，以便它们用作心脏贴片。

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