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首页> 外文期刊>Advanced Functional Materials >Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs
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Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs

机译：微阵列补丁：在提供可溶性药物不良时面临的挑战中戳了一个洞

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摘要

Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with over two-thirds of promising new chemical entities failing to enter a clinical setting due to solubility issues. Although oral formulations have made some impact, alternative enhancement strategies for administration of such molecules are actively sought. Over the last decade, innovation on a global scale has enabled the expansion of the frontiers of microarray patches (MAPs) further than ever before. Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now becoming a viable strategy for the immediate and long-acting delivery of poorly soluble drugs through the skin. This together with the advantages of transdermal administration over the oral and parenteral routes, make of MAPs an appealing platform for the development of products with increased patient compliance. Undoubtedly, MAPs will soon become a readily available therapeutic alternative, and experts from academia, industry and regulatory bodies are working together aiming to facilitate the progression of MAPs toward safe and effective clinical use. This review aims to highlight the ability of MAPs to deliver poorly soluble actives, discuss the mechanisms behind in-skin drug absorption, and evaluate the future direction of the field.
机译：可溶性药物差异较差的药物超过60％的目前销售药品，超过三分之二有超过三分之二的新化学实体未能由于溶解性问题进入临床环境。虽然口服配方已经产生了一些影响，但积极寻求替代促进这些分子的策略。在过去十年中，全球范围内的创新使得微阵列补丁（地图）的边界的扩展优于以前。最初设计用于负载低剂量的亲水和有效的治疗剂，现在正在成为通过皮肤直接和长期易溶的药物的可行策略。这与透皮给药在口腔和肠胃外路线上的优点，使MAPS成为开发产品的吸引力平台，以增加患者遵守性。毫无疑问，地图将很快成为一项易于可用的治疗性替代方案，以及学术界，工业和监管机构的专家都在共同努力，旨在促进地图的进展，以安全有效的临床使用。本综述旨在突出地图提供差异不良活性的能力，讨论皮肤内吸毒后面的机制，并评估该领域的未来方向。

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  • 来源
    《Advanced Functional Materials》 |2021年第1期|2005792.1-2005792.27|共27页
  • 作者

    Paredes Alejandro J.; McKenna Peter E.; Ramoller Inken K.; Naser Yara A.; Volpe-Zanutto Fabiana; Li Mingshan; Abbate M. T. A.; Zhao Li; Zhang Chunyang; Abu-Ershaid Juhaina M.; Dai Xianbing; Donnelly Ryan F.;

  • 作者单位

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland|Isra Univ Sch Pharm Amman Jordan;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

    Queens Univ Belfast Sch Pharm Med Biol Ctr 97 Lisburn Rd Belfast BT9 7BL Antrim North Ireland;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    hydrophobic drugs; microarray patches; microneedles; nanocrystals; poorly soluble drugs;

    机译：疏水药;微阵列斑块;微针;纳米晶体;可溶性药物差;

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