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Intelligent Silk Fibroin Based Microneedle Dressing (i-SMD)

机译：基于智能丝素蛋白的微针敷料（I-SMD）

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摘要

Wounds, especially those caused by chronic diseases, are severe threats to human health. To facilitate their recovery, considerable efforts have been devoted to the generation of wound tissues and the detection of wound biomarkers. Here, an intelligent origami silk fibroin microneedle-structured dressing (i-SMD) with a smart drug release system, biochemical sensing, and physiological monitoring ability for epidermal sensing and wound healing, is presented. By utilizing temperature-responsiveN-isopropylacrylamide (NIPAM) hydrogel and inverse opal (IO) photonic crystals (PCs) as a smart drug release system, controllable drug release is achieved on the i-SMD. The patterned microfluidic channels on the i-SMD and IO PCs enable the liquid to flow spontaneously in the channels, thereby achieving sensitive multiple biochemical analysis of inflammatory factors; meanwhile, microelectronic circuits integrated on the i-SMD enable sensitive motion monitoring. Notably, the performance of i-SMD in facilitating wound healing is demonstrated by treating full-thickness cutaneous wounds in a diabetic mouse model, indicating the remarkable prospects of i-SMD in wound management and other related biomedical fields.
机译：伤口，尤其是慢性疾病引起的伤口，对人类健康是严重的威胁。为了促进他们的康复，已经致力于产生伤口组织和伤口生物标志物的检测。在这里，提出了一种具有智能药物释放系统，生物化学传感和表皮传感和伤口愈合的生物化学传感和生理监测能力的智能折纸丝纤维素微针结构敷料（I-SMD）。通过利用温度响应的异丙基丙烯酰胺（NIPAM）水凝胶和反蛋白石（IO）光子晶体（PCS）作为智能药物释放系统，在I-SMD上实现可控药物释放。 I-SMD和IO PC上的图案化的微流体通道使液体能够在通道中自发地流动，从而实现炎症因素的敏感多种生化分析;同时，集成在I-SMD上的微电子电路使能敏感运动监控。值得注意的是，通过在糖尿病小鼠模型中治疗全厚的皮肤伤口来证明I-SMD在促进伤口愈合方面的性能，表明伤口管理中I-SMD的显着前景和其他相关生物医学领域。

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