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Enzyme-Degradable 3D Multi-Material Microstructures

机译：酶降解3D多材料微观结构

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摘要

There exists a growing need for smart materials suitable for use in biomedical applications. Herein, a photoresist that can be used to fabricate a biocompatible material entirely degradable by the enzyme chymotrypsin is introduced. The photoresist is based on a crosslinker with a tyramine moiety that is recognized and cleaved by the enzyme chymotrypsin. Macroscopic films as well as microstructures are fabricated via the use of direct laser writing. Multi-material boxing ring microstructures are generated and selectively degraded by the enzyme. Cell biocompatibility studies indicate that cells are able to attach and proliferate over one week on the material. A photoresist that is biocompatible and can be entirely removed by a biocompatible stimulus such as an enzyme can potentially be used as an easily removed tissue engineering scaffold and is especially promising for basic cell biology research.
机译：对于适用于生物医学应用的智能材料，存在越来越多的需求。在此，引入了可用于制造完全可通过酶Chymotrypsin可降解的生物相容性材料的光致抗蚀剂。光致抗蚀剂基于具有酪胺部分的交联剂，其被酶胰蛋白酶识别和切割。通过使用直接激光书写制造宏观薄膜以及微观结构。产生多材料拳击环微结构并选择性地通过酶降解。细胞生物相容性研究表明，细胞能够在材料上一周内附着和增殖。一种生物相容性并且可以通过生物相容性刺激的光致抗蚀剂如酶如酶完全除去，可能用作易于移除的组织工程支架，并且对于基础细胞生物学研究特别有前途。

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  • 来源
    《Advanced Functional Materials》 |2021年第3期|2006998.1-2006998.8|共8页
  • 作者

    Graefe David; Gernhardt Marvin; Ren Jiongyu; Blasco Eva; Wegener Martin; Woodruff Maria Ann; Barner-Kowollik Christopher;

  • 作者单位

    Queensland Univ Technol QUT Ctr Mat Sci Sch Chem & Phys 2 George St Brisbane Qld 4000 Australia;

    Queensland Univ Technol QUT Ctr Mat Sci Sch Chem & Phys 2 George St Brisbane Qld 4000 Australia;

    Queensland Univ Technol QUT Sci & Engn Fac 2 George St Brisbane Qld 4000 Australia;

    Karlsruhe Inst Technol KIT Inst Nanotechnol Hermann von Helmholtz Pl 1 D-76344 Eggenstein Leopoldshafen Germany;

    Karlsruhe Inst Technol KIT Inst Nanotechnol Hermann von Helmholtz Pl 1 D-76344 Eggenstein Leopoldshafen Germany;

    Queensland Univ Technol QUT Sci & Engn Fac 2 George St Brisbane Qld 4000 Australia;

    Queensland Univ Technol QUT Ctr Mat Sci Sch Chem & Phys 2 George St Brisbane Qld 4000 Australia|Karlsruhe Inst Technol KIT Inst Nanotechnol Hermann von Helmholtz Pl 1 D-76344 Eggenstein Leopoldshafen Germany;

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  • 正文语种 eng
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  • 关键词

    biocompatibility; direct laser writing; enzyme-degradability; microstructures;

    机译：生物相容性;直接激光书写;酶降解性;微观结构;

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