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首页> 外文期刊>Advanced Functional Materials >NIR Light-Driven Bi_2Se_3-Based Nanoreactor with 'Three in One' Hem in-Assisted Cascade Catalysis for Synergetic Cancer Therapy
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NIR Light-Driven Bi_2Se_3-Based Nanoreactor with 'Three in One' Hem in-Assisted Cascade Catalysis for Synergetic Cancer Therapy

机译：基于NIR光驱动的BI_2SE_3的纳米反应器，具有“三个”中的“三个”中辅助级联催化作用，用于协同癌症治疗

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Photocatalytic semiconductor-based nanoreactors, that convert nontoxic molecules into toxic ones for cancer therapy, have attracted great interest. However, its therapeutic efficiency is limited by the fast electron-hole recombination within a narrow bandgap, low oxidative damage of H(2)O(2)(,)and tumor hypoxia. Herein, aggregation-limited hemin is introduced onto Bi(2)Se(3)nanoparticles for successively solving these problems. The nanoreactor (Bi2Se3@hemin-(G-H)-HA NPs) is obtained through adamantane modified hemin and beta-cyclodextrin modified hyaluronic acid complexing and wrapping on Bi(2)Se(3)NPs via host-guest and electrostatic interaction. Once irradiated by NIR light, the hemin assists Bi(2)Se(3)to separate electron-hole pairs and catalyze endogenous H2O to generate vast H2O2, resulting in a 3.9-fold higher H(2)O(2)generation than that of individual Bi2Se3. Subsequently, H(2)O(2)is catalyzed by aggregation-limited hemin to generate highly toxic center dot OH and center dot O-2(-), which improves the total reactive oxygen species generation of Bi2Se3@hemin-(G-H)-HA by 10.8-fold compared to that of Bi(2)Se(3)NPs. Importantly, the cytotoxicity result exhibits a death rate of HepG2 cells of above 90%, even though in a simulated hypoxic environment. Additionally, the in vivo result indicates this nanoreactor realizes an synergetic anticancer effect with a tumor inhibition rate of 92.3%. Overall, such a nanoreactor with hemin-assisted cascade catalysis is a promising candidate for improving therapeutic efficacy.
机译：光催化半导体基纳米反应器，将无毒分子转化为毒性癌症治疗的毒性，引起了极大的兴趣。然而，其治疗效率受到窄带隙内的快速电子空穴重组的限制，H（2）O（2）（，）和肿瘤缺氧的低氧化损伤。在此，将聚集限制血红素引入BI（2）SE（3）纳米颗粒上，以依次解决这些问题。通过Adamantane改性的血红蛋白和β-环糊精修饰的透明质酸络合和通过宿主 - 访客和静电相互作用将透明质酸络合和包裹在Bi（2）Se（3）NPS上缠绕来获得纳米反应器（Bi2Se3 @血红素（G-H）-Ha NPS）。一旦被NIR光照射，血红素辅助BI（2）SE（3）分离电子 - 空穴对并催化内源性H2O以产生大量的H2O2，导致3.9倍的H（2）O（2）生成个人bi2se3。随后，H（2）O（2）通过聚集限制血红素催化，以产生高度毒性中心点OH和中心点O-2（ - ），其改善了Bie2se3的总反应性氧物种产生了@ Hemin-（GH）与Bi（2）SE（3）NPS相比，HA达10.8倍。重要的是，即使在模拟的缺氧环境中，细胞毒性结果表现出高于90％以上的HepG2细胞的死亡率。另外，体内结果表明该纳米反应器实现了肿瘤抑制率为92.3％的协同抗癌效果。总的来说，这种具有血液辅助级联催化的纳米反应器是提高治疗效果的有希望的候选者。

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  • 来源
    《Advanced Functional Materials》 |2020年第52期|2006883.1-2006883.13|共13页
  • 作者

    Niu Xiaoyan; Liu Yang; Li Xiaomin; Wang Wei; Yuan Zhi;

  • 作者单位

    Nankai Univ Coll Chem Inst Educ Key Lab Funct Polymer Mat Minist Educ Tianjin 300071 Peoples R China;

    Nankai Univ Coll Chem Inst Educ Key Lab Funct Polymer Mat Minist Educ Tianjin 300071 Peoples R China;

    Nankai Univ Coll Chem Inst Educ Key Lab Funct Polymer Mat Minist Educ Tianjin 300071 Peoples R China;

    Nankai Univ Coll Chem Inst Educ Key Lab Funct Polymer Mat Minist Educ Tianjin 300071 Peoples R China;

    Nankai Univ Coll Chem Inst Educ Key Lab Funct Polymer Mat Minist Educ Tianjin 300071 Peoples R China;

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  • 关键词

    Bi2Se3; cascade reactions; hemin; heterostructures; NIR light driven;

    机译：Bi2se3;级联反应;血红素;异质结构;尼尔光线驱动;

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