Heterogeneous Structural Color Microfibers for Cardiomyocytes Tug-of-War

Chen Zhuoyue; Yu Yunru; Guo Jiahui; Sun Lingyu; Zhao Yuanjin

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Heterogeneous Structural Color Microfibers for Cardiomyocytes Tug-of-War

机译：用于心肌细胞的异质结构颜色微纤维拔河

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Cellular mechanics are of great significance in biological functions and have stimulated the development of various techniques to detect and analyze it. Here, a novel heterogeneous structural color microfiber designed for dynamic cardiac mechanics sensing is presented. The microfiber is fabricated by the programmed injection microfluidic spinning method, which achieves the alternative injection of different solutions and generates axial heterogeneous components. This microfiber contains non-close-packed colloidal arrays for quantitative optical sensing and bioactive methacrylated gelatin (GelMA) for cardiac culture. When the cultivated cardiomyocytes recover autonomous beating cycles, the structural color section would be stretch and exhibits synchronous stretch cycles with dynamic color variation and wavelength shifts, which transforms microcosmic cell-generated force into macroscopic optical signals. In addition, the single-cell-level mechanics detecting platform can be achieved by tuning the size and diameter of the heterogeneous structural color microfibers. These features contribute to the heterogeneous structural color microfiber to be an ideal platform for biomedical fields.

机译：细胞机制在生物学功能方面具有重要意义，并刺激了各种技术的发展来检测和分析它。这里，提出了一种用于动态心脏力学传感的新型异构结构颜色微纤维。通过编程的注射微流体纺丝方法制造超细纤维，其达到不同溶液的替代注入并产生轴向异质组分。该微纤维含有非封闭填充的胶体阵列，用于心脏培养的定量光学传感和生物活性甲基丙烯酸明胶（GELMA）。当培养的心肌细胞恢复自主搏动循环时，结构颜色部分将是拉伸的并且具有动态颜色变化和波长偏移的同步拉伸循环，其将微观镜电池产生的力转化为宏观光学信号。另外，通过调节异构结构颜色微纤维的尺寸和直径，可以实现单细胞级机械检测平台。这些特征有助于异质结构色素微纤维是成为生物医学领域的理想平台。

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来源
《Advanced Functional Materials》 |2021年第9期|2007527.1-2007527.10|共10页
作者
Chen Zhuoyue; Yu Yunru; Guo Jiahui; Sun Lingyu; Zhao Yuanjin;
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作者单位

Nanjing Univ Dept Rheumatol & Immunol Inst Translat Med Affiliated Drum Tower Hosp Med Sch Nanjing 210008 Peoples R China|Southeast Univ Sch Biol Sci & Med Engn State Key Lab Bioelect Nanjing 210096 Peoples R China;

Southeast Univ Sch Biol Sci & Med Engn State Key Lab Bioelect Nanjing 210096 Peoples R China;

Southeast Univ Sch Biol Sci & Med Engn State Key Lab Bioelect Nanjing 210096 Peoples R China;

Southeast Univ Sch Biol Sci & Med Engn State Key Lab Bioelect Nanjing 210096 Peoples R China;

Nanjing Univ Dept Rheumatol & Immunol Inst Translat Med Affiliated Drum Tower Hosp Med Sch Nanjing 210008 Peoples R China|Southeast Univ Sch Biol Sci & Med Engn State Key Lab Bioelect Nanjing 210096 Peoples R China;

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正文语种 eng
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关键词
cardiomyocyte; fiber; microfluidics; organ on a chip; structural color;

机译：心肌细胞;纤维;微流体;芯片上的器官;结构颜色;

Heterogeneous Structural Color Microfibers for Cardiomyocytes Tug-of-War

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