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首页> 外文期刊>Advanced Functional Materials >Upconversion Nanoparticles Hybridized Cyanobacterial Cells for Near-Infrared Mediated Photosynthesis and Enhanced Photodynamic Therapy
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Upconversion Nanoparticles Hybridized Cyanobacterial Cells for Near-Infrared Mediated Photosynthesis and Enhanced Photodynamic Therapy

机译：用于近红外介导的光合作用和增强的光动力疗法的上转化纳米颗粒杂交的蓝细菌细胞

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摘要

The hypoxic hallmark of tumor has aroused substantial burdens on a variety of therapeutic modalities including photodynamic therapy (PDT). Recently, biological oxygen evolution enabled by photosynthetic cyanobacterial cells has emerged as one of the most advanced and promising tissue oxygenation strategies, which is particularly beneficial for in situ tumor-PDT. Herein, a near infrared-driven PDT platform based on the photosynthetic cyanobacterial cells hybridized with photosensitizer rose bengal (RB)-loaded upconversion nanoparticles, named as UR-Cyan cells, is reported. Upon the irradiation of 980 nm laser and its upconversions to shorter wavelengths, the formulated UR-Cyan cells are both photosynthetically active for oxygen production and photosensitive for the subsequent singlet oxygen generation by the photosensitizer, resulting in enhanced and sustainable PDT efficacy against tumor cells/tissues. The present design offers a practical approach to conquer the hypoxic burden of PDT operations against a wide range of pathological lesions with excellent biocompatibility and clinical promises.
机译：肿瘤的缺氧标志引起了各种治疗方式的大量负担，包括光动力治疗（PDT）。最近，由光合胞间细胞通过的生物氧气进化是最先进和有前途的组织氧合策略之一，这对于原位肿瘤-PDT特别有益。这里，报道了基于与光敏剂升降叶（RB）载荷的上变化纳米颗粒杂交的光合紫杉杆菌细胞的近红外驱动的PDT平台，被称为UR-Cyan细胞。在照射980nm激光和其上转移到更短的波长时，配制的UR-Cyan细胞均为光敏性的氧产生和光敏，用于光敏剂的后续汗基产生，导致对肿瘤细胞的增强和可持续的PDT功效/组织。目前的设计提供了一种实用的方法，以征服PDT操作的缺氧负担，以及具有优异的生物相容性和临床承诺的各种病理病变。

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  • 来源
    《Advanced Functional Materials》 |2021年第16期|2010196.1-2010196.10|共10页
  • 作者

    Huo Minfeng; Liu Peilei; Zhang Linlin; Wei Chenyang; Wang Liying; Chen Yu; Shi Jianlin;

  • 作者单位

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China|Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China|Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China|Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China|Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China;

    Tongji Univ Shanghai Peoples Hosp 10 Sch Med Shanghai 200072 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China|Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine Shanghai 200050 Peoples R China|Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    cyanobacterial; photodynamic therapy; photosensitization; photosynthesis; upconversion nanoparticles;

    机译：蓝杆菌;光动力疗法;光敏化;光合作用;上转换纳米颗粒;

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