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Partially Functional Electrode Modifications for Rapid Detection of Dopamine in Urine

机译：部分功能电极改性，用于快速检测尿液中多巴胺

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摘要

Designing functional materials as electrode coatings to transduce high-quality information about redox molecules in biofluids is crucial for developing the next-generation medical devices. Rapidly analyzing the neurotransmitter dopamine (DA) urinary levels can enable point-of-care testing for neuroendocrine tumors. A novel sensing electrodes array modified with biopolymer chitosan and electrocatalytic carbon nanotube films that can generate cross-reactive electrochemical signals from complex biofluids, such as undiluted urine, is presented. By generating cross-reactive signals, the feasibility of quantifying DA levels from unprocessed urine samples is demonstrated. The films' electrochemical activity is characterized and modeled the additive effect of the main redox interferants in urine (norepinephrine and uric acid) on the generated electrochemical signals that overlap and mask the electrochemical signature of DA. Finally, the feasibility of successfully quantifying urinary DA levels is demonstrated by investigating two calibration approaches: 1) using a synthetic solution (1.15 mu m root mean squared error (RMSE) and 4.2 mu m limit-of-detection (LoD) values), and 2) directly using the urine samples (2.5 mu m RMSE and 9.3 mu m LoD values). The outcome of this work will enhance the understanding of the overlapping and masking electrochemical signatures and their interactions with functional materials, providing better analytical tools to differentiate redox molecules in highly complex biofluids.
机译：设计功能材料作为电极涂层，以转换有关生物流体中的氧化还原分子的高质量信息对于开发下一代医疗器械至关重要。快速分析神经递质多巴胺（DA）尿液水平可为神经内分泌肿瘤进行护理点测试。提出了一种具有生物聚合物壳聚糖和电催化碳纳米管膜改性的新型感测电极阵列，其能够产生来自复杂生物流体的交叉反应电化学信号，例如未稀释的尿液。通过产生交叉反应性信号，证明了来自未加工尿液样本的定量DA水平的可行性。薄膜的电化学活性表征并建模了主氧化还原干扰剂在尿液（Norepinephrine和尿酸）中的添加剂效果，其在所产生的电化学信号中重叠和掩盖DA的电化学签名。最后，通过使用合成溶液调查两种校准方法（1.15Mu M根平均平方误差（RMSE）和4.2μm检测限制（LOD）值）来证明成功定量尿DA水平的可行性2）直接使用尿液样本（2.5μmrmse和9.3 mu m lod值）。这项工作的结果将增强对具有功能材料的重叠和掩蔽电化学签名的理解及其与功能材料的相互作用，提供更好的分析工具，以将氧化还原分子分化为高度复杂的生物流体。

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  • 来源
    《Advanced Functional Materials》 |2021年第17期|2004146.1-2004146.10|共10页
  • 作者

    Shukla Rajendra P.; Aroosh Matan; Matzafi Alon; Ben-Yoav Hadar;

  • 作者单位

    Ben Gurion Univ Negev Nanobioelect Lab NBEL Dept Biomed Engn IL-8410501 Beer Sheva Israel|Ben Gurion Univ Negev Ilse Katz Inst Nanoscale Sci & Technol IL-8410501 Beer Sheva Israel;

    Ben Gurion Univ Negev Nanobioelect Lab NBEL Dept Biomed Engn IL-8410501 Beer Sheva Israel|Ben Gurion Univ Negev Ilse Katz Inst Nanoscale Sci & Technol IL-8410501 Beer Sheva Israel;

    Ben Gurion Univ Negev Nanobioelect Lab NBEL Dept Biomed Engn IL-8410501 Beer Sheva Israel|Ben Gurion Univ Negev Ilse Katz Inst Nanoscale Sci & Technol IL-8410501 Beer Sheva Israel;

    Ben Gurion Univ Negev Nanobioelect Lab NBEL Dept Biomed Engn IL-8410501 Beer Sheva Israel|Ben Gurion Univ Negev Ilse Katz Inst Nanoscale Sci & Technol IL-8410501 Beer Sheva Israel;

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  • 正文语种 eng
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  • 关键词

    chemometrics; electrode coatings; miniaturized biosensors; neurotransmitters;

    机译：化学计量学;电极涂层;小型化生物传感器;神经递质;

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