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首页> 外文期刊>Advanced Functional Materials >Bioinspired Highly Anisotropic, Ultrastrong and Stiff, and Osteoconductive Mineralized Wood Hydrogel Composites for Bone Repair
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Bioinspired Highly Anisotropic, Ultrastrong and Stiff, and Osteoconductive Mineralized Wood Hydrogel Composites for Bone Repair

机译：Bioinspired高度各向同性，超自推孔和僵硬，骨压矿化木水凝胶复合材料用于骨骼修复

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摘要

Anisotropic hydrogels mimicking the biological tissues with directional functions play essential roles in damage-tolerance, cell guidance and mass transport. However, conventional synthetic hydrogels often have an isotropic network structure, insufficient mechanical properties and lack of osteoconductivity, which greatly limit their applications for bone repair. Herein, inspired by natural bone and wood, a biomimetic strategy is presented to fabricate highly anisotropic, ultrastrong and stiff, and osteoconductive hydrogel composites via impregnation of biocompatible hydrogels into the delignified wood followed by in situ mineralization of hydroxyapatite (HAp) nanocrystals. The well-aligned cellulose nanofibrils endow the composites with highly anisotropic structural and mechanical properties. The strong intermolecular bonds of the aligned cellulose fibrils and hydrogel/wood interaction, and the reinforcing nanofillers of HAp enable the composites remarkable tensile strength of 67.8 MPa and elastic modulus of 670 MPa, three orders of magnitude higher than those of conventional alginate hydrogels. More importantly, the biocompatible hydrogel together with aligned HAp nanocrystals could effectively promote osteogenic differentiation in vitro and induce bone formation in vivo. The bone ingrowth into the hydrogel composite scaffold also yields good osteointegration. This study provides a low-cost, eco-friendly, feasible, and scalable approach for fabricating anisotropic, strong, stiff, hydrophilic, and osteoconductive hydrogel composites for bone repair.
机译：具有方向性功能的各向异性水凝胶模拟生物组织，在损伤耐受性，细胞引导和大规模运输中起主要作用。然而，常规的合成水凝胶通常具有各向同性网络结构，机械性能不足和缺乏骨导电性，这极大地限制了它们的骨骼修复的应用。这里，由天然骨和木材的启发，提出了一种仿生策略，以通过将生物相容性水凝胶浸渍到上磷酸盐中，以制造高各向异性，超龙和硬度和骨凝胶复合材料，然后在羟基磷灰石（HAP）纳米晶体中原位矿化。良好对准的纤维素纳米纤维赋予复合材料具有高各向异性结构和机械性能。对齐的纤维素原纤维和水凝胶/木质相互作用的强分子结合，以及HAP的增强纳米填料使复合材料具有67.8MPa的显着拉伸强度和670MPa的弹性模量，比常规藻酸盐水凝胶高三个数量级。更重要的是，生物相容性水凝胶与对齐的Hap纳米晶体一起可以有效地促进体外骨质发生分化并在体内诱导骨形成。将骨扩散到水凝胶复合支架中也产生良好的骨囊肿。本研究提供了一种低成本，环保，可行的和可扩展性的方法，用于制造各向异性，强，刚性，亲水性和骨凝胶复合材料，用于骨骼修复。

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  • 来源
    《Advanced Functional Materials》 |2021年第20期|2010068.1-2010068.10|共10页
  • 作者

    Wang Xiaofei; Fang Ju; Zhu Weiwei; Zhong Chuanxin; Ye Dongdong; Zhu Mingyu; Lu Xiong; Zhao Yusheng; Ren Fuzeng;

  • 作者单位

    Southern Univ Sci & Technol Dept Mat Sci & Engn Shenzhen 518055 Guangdong Peoples R China|Southern Univ Sci & Technol Acad Adv Interdisciplinary Studies AAIS Shenzhen 518055 Guangdong Peoples R China;

    Southern Univ Sci & Technol Dept Mat Sci & Engn Shenzhen 518055 Guangdong Peoples R China;

    Southern Univ Sci & Technol Dept Mat Sci & Engn Shenzhen 518055 Guangdong Peoples R China;

    Southern Univ Sci & Technol Dept Mat Sci & Engn Shenzhen 518055 Guangdong Peoples R China|Hong Kong Baptist Univ Sch Chinese Med Inst Adv Translat Med Bone & Joint Dis Hong Kong 999077 Peoples R China;

    Wuyi Univ Sch Text Mat & Engn Jiangmen 529020 Guangdong Peoples R China;

    Southern Univ Sci & Technol Dept Mat Sci & Engn Shenzhen 518055 Guangdong Peoples R China;

    Southwest Jiaotong Univ Sch Mat Sci & Engn Minist Educ Key Lab Adv Technol Mat Chengdu 621000 Sichuan Peoples R China;

    Southern Univ Sci & Technol Acad Adv Interdisciplinary Studies AAIS Shenzhen 518055 Guangdong Peoples R China;

    Southern Univ Sci & Technol Dept Mat Sci & Engn Shenzhen 518055 Guangdong Peoples R China;

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  • 正文语种 eng
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  • 关键词

    anisotropic hydrogels; bioinspired materials; bone repair; high strength; osteoconductivity;

    机译：各向异性水凝胶;Bioinspired材料;骨骼修复;高强度;骨导电性;

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