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首页> 外文期刊>Advanced Functional Materials >Synthesis of MoSe_2/CoSe_2 Nanosheets for NIR-Enhanced Chemodynamic Therapy via Synergistic In-Situ H_2O_2 Production and Activation
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Synthesis of MoSe_2/CoSe_2 Nanosheets for NIR-Enhanced Chemodynamic Therapy via Synergistic In-Situ H_2O_2 Production and Activation

机译：通过协同原位H_2O_2生产和激活来合成NIR增强化学动力学治疗的MOSE_2 / COSE_2纳米蛋白酶

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摘要

Currently, the limited intratumoral H2O2 level restricts the development of chemodynamic therapy (CDT). Herein, MoSe2/CoSe2@PEG nanosheets are prepared to reveal NIR‐photocatalytic H2O2 generation to insure the intracellular H2O2 supplement. The formation mechanism is investigated, showing the dissolved O2 and photo‐excited electrons to determine H2O2 production via sequential single‐electron transfer process. The experimental data and density functional theory calculation further display their typical‐II heterostructure, which possesses the effective charge separation and nearly four times H2O2 generation than MoSe2@PEG. In addition, the nanocomposites also reveal the peroxidase/catalase activity, making the in‐situ H2O2 activation and ·OH generation. And, the O2 production derived from catalase‐mimic activity not only relieves hypoxia but also offers the source for H2O2 production. Because of the decreased resistance for charge transfer, MoSe2/CoSe2@PEGs also reveal more than three times enzyme‐activity for MoSe2@PEG. With the narrow band gap and high NIR‐harvest, MoSe2/CoSe2@PEG exhibits the great photothermal converting ability (62.5%). MoSe2/CoSe2@PEG reveals the novel biodegradation, and most of them can be eliminated via urine and feces within 2 weeks. Here, the computed tomography/magnetic resonance imaging/photothermal imaging and the synergistic photothermal therapy/CDT treatments further make sure potential application on anticancer.
机译：目前，有限的肿瘤内H2O2水平限制了化学热疗法的发展（CDT）。在此，制备MOSE2 / COSE2 @ PEG纳米片以显示NIR-光催化H2O2代，以确保细胞内H2O2补充剂。研究了形成机制，显示溶解的O 2和光激发电子以通过顺序单电子转移过程确定H2O2产生。实验数据和密度官能理论计算进一步显示其典型的II异质结构，其具有比MOSE2 @ PEG的有效电荷分离和近四倍的H2O2。另外，纳米复合材料还揭示过氧化物酶/过氧化氢酶活性，使原位H2O2活化和哦生成。并且，来自过氧化氢酶 - 模拟活动的O2生产不仅可以缓解缺氧，而且还提供了H2O2生产的来源。由于电荷转移的阻力降低，MOSE2 / COSE2 @ PEG还揭示了MOSE2 @ PEG的三倍以上的酶活性。随着窄带隙和高Nir收获，MOSE2 / COSE2 @ PEG表现出很大的光热转换能力（62.5％）。 MOSE2 / COSE2 @ PEG揭示了新的生物降解，大多数通过尿液和粪便可以在2周内消除。这里，计算断层摄影/磁共振成像/光热成像和协同光热疗/ CDT处理进一步确保潜在的抗癌施用。

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  • 来源
    《Advanced Functional Materials》 |2021年第8期|2008420.1-2008420.13|共13页
  • 作者

    Yang Li; Ran Jia; Huiming Lin; Xilin Sun; Fengyu Qu;

  • 作者单位

    Key Laboratory of Photochemical Biomaterials and Energy Storage Materials College of Chemistry and Chemical Engineering Harbin Normal University Harbin Heilongjiang 150025 China;

    Institute of Theoretical Chemistry Jilin University Changchun Jilin 130023 China;

    Key Laboratory of Photochemical Biomaterials and Energy Storage Materials College of Chemistry and Chemical Engineering Harbin Normal University Harbin Heilongjiang 150025 China|Laboratory for Photon and Electronic Bandgap Materials Ministry of Education Harbin Normal University Harbin Heilongjiang 150025 China;

    NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Molecular Imaging Research Center (MIRC) Harbin Medical University Harbin Heilongjiang 150028 China|TOF-PET/CT/MR Center The Fourth Hospital of Harbin Medical University Harbin Heilongjiang 150028 China;

    Key Laboratory of Photochemical Biomaterials and Energy Storage Materials College of Chemistry and Chemical Engineering Harbin Normal University Harbin Heilongjiang 150025 China|Laboratory for Photon and Electronic Bandgap Materials Ministry of Education Harbin Normal University Harbin Heilongjiang 150025 China;

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  • 正文语种 eng
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  • 关键词

    chemodynamic therapy; nanozyme; photocatalytic H 2O 2‐; photothermal therapy; typical‐II nanoheterostructure;

    机译：化学动力学化学;纳米型;光拷贝H 2O 2-;Photohemeters疗法;典型的Iinoheterosure;

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