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Bio-Inspired Ionic Skin for Theranostics

机译：生物启发用于Theranostics的离子皮肤

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摘要

The first-generation ionic skins demonstrate great advantages in the tunable mechanical properties, high transparency, ionic conductivities, and multiple sensory capacities. However, little attention is paid to the interfacial interactions among the ambient environment, natural organisms, and the artificial skins. In particularly, current ionic skins based on traditional synthetic hydrogels suffer from dehydration in vitro and lack of substance communication channels with biological tissues. Herein, this work develops a bio-inspired hydrogel to address these key challenges. The hydrogel is designed with natural moisturizing factors to lock water, biomineral ions to transmit signals, and biomimetic gradient channels to transport substances from non-living to living interfaces. It is stable in ambient condition, adhesive and hydrated on mammal skins, and capable of non-invasive point-to-point theranostics. This theranostic ionic skin realizes sensitive detection, enhanced treatment efficacy, and reduced side effects toward major diseases in vitro. It will shed light on the hydrogel bioelectronics with excellent biocompatibility, bio-protection, and bio-integration for human-machine interfaces and intelligent theranostics.
机译：第一代离子皮肤在可调机械性能，高透明度，离子电导率和多种感官能力中表现出具有很大的优点。然而，很少关注环境环境，天然生物和人造皮肤之间的界面相互作用。特别地，基于传统合成水凝胶的电流离子皮在体外脱水，并且缺乏具有生物组织的物质通信通道。在此，这项工作开发了生物激发的水凝胶以解决这些关键挑战。水凝胶采用天然保湿因子设计，以锁定水，生物纲离子传递信号，以及仿生梯度通道，以将来自非生活中的物质运输到生活界面。它在环境条件下稳定，粘合剂和水合在哺乳动物皮肤上，并且能够能够进行非侵入性点对点的治疗方法。这种治疗离子皮肤意识到敏感的检测，增强治疗效果，并对体外主要疾病的副作用减少。它将阐明水凝胶生物电联的生物能力，生物相容性，生物保护和人机界面的生物集成，以及智能的Theranostics。

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  • 来源
    《Advanced Functional Materials》 |2021年第8期|2008020.1-2008020.9|共9页
  • 作者

    Lei Zhouyue; Zhu Wencheng; Zhang Xingcai; Wang Xiongjun; Wu Peiyi;

  • 作者单位

    Donghua Univ State Key Lab Modificat Chem Fibers & Polymer Mat Coll Chem Chem Engn & Biotechnol Ctr Adv Low Dimens Mat Shanghai 201620 Peoples R China|Harvard Univ John A Paulson Sch Engn & Appl Sci Cambridge MA 02138 USA;

    Chinese Acad Sci Shanghai Inst Biochem & Cell Biol Shanghai 201203 Peoples R China;

    Harvard Univ John A Paulson Sch Engn & Appl Sci Cambridge MA 02138 USA;

    Chinese Acad Sci Univ Chinese Acad Sci Inst Nutr & Hlth Sci CAS Key Lab Tissue Microenvironm & Tumor Shanghai 201203 Peoples R China;

    Donghua Univ State Key Lab Modificat Chem Fibers & Polymer Mat Coll Chem Chem Engn & Biotechnol Ctr Adv Low Dimens Mat Shanghai 201620 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    bio#8208; inspired materials; hydrogels; ionic skins; ionotronics; soft materials;

    机译：生物＆＃8208;灵感材料;水凝胶;离子皮;离子鸟类;软材料;

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