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Persistent Luminescence Immune Hydrogel for Photodynamic-Immunotherapy of Tumors In Vivo

机译：持续发光免疫水凝胶，用于体内肿瘤的光动力学 - 免疫疗法

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摘要

Persistent luminescence material (PLM)-based photodynamic therapy (PDT) has shown tremendous promise in tumor elimination via avoiding continuous external light illumination. In addition, the tumor-associated antigens produced by PDT can trigger systemic antitumor immune responses, but only exhibit a limited immunotherapy effect. Herein, a persistent luminescence immune hydrogel is developed via a "turning solid into gel" strategy by introducing a PLM and an immunoadjuvant (R837) into an alginate-Ca2+ hydrogel for rechargeable photodynamic-immunotherapy of tumors, for the first time. The designed PLM-R837-ALG hydrogel exhibits the intact persistent luminescence of the PLM, 100% of utilization efficiency of the hydrophobic precursors, good biocompatibility and syringeability, and can be easily injected into tumors to serve as an internal light source for efficiently activating photosensitizers to induce a sustained PDT effect. Moreover, the loaded R837 can significantly amplify the immunogenicity of tumor-associated antigens originating from PL sensitized PDT, thereby leading to a powerful immune response to suppress tumors in vivo. The proposed PL-based photodynamic-immunotherapy provides a novel combined tumor treatment paradigm.
机译：基于恒定外光照明的持续发光材料（PLM）的光动力疗法（PCT）在肿瘤消除中显示出巨大的希望。此外，PDT产生的肿瘤相关抗原可以引发全身抗肿瘤免疫应答，但仅表现出有限的免疫治疗效果。在此，通过将PLM和免疫衰竭（R837）引入藻酸盐-CO2 +水凝胶中，通过“转向固体成凝胶”策略进行持续发光免疫水凝胶，首次通过将PLM和免疫衰竭（R837）加入藻酸钠-CO2 +水凝胶中进行可充电的光动力学 - 免疫疗法。设计的PLM-R837-ALG水凝胶具有PLM的完整持续发光，100％的利用效率的疏水性前体，良好的生物相容性和系压性，并且可以容易地注入肿瘤中以用作有效激活光敏剂的内部光源诱导持续的PDT效应。此外，负载的R837可以显着扩增源自PL敏化PDT的肿瘤相关抗原的免疫原性，从而导致强大的免疫应答，以抑制体内肿瘤。所提出的基于PL基光动力学 - 免疫疗法提供了一种新的组合肿瘤治疗范式。

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