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Graphene Oxide Based Fluorescent DNA Aptasensor for Liver Cancer Diagnosis and Therapy

机译：基于石墨烯氧化物的荧光DNA适用于肝癌诊断和治疗的Aptasensor

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摘要

Graphene oxide (GO)-based fluorescent DNA aptasensors are promising nanomaterials in bioassays owing to the fluorescent ultrasensitivity and target identification ability. However, their in vivo application remains an appealing yet significantly challenging task. In this contribution, for the first time, a nanomaterial for in vivo diagnosis and therapy of liver tumors is demonstrated. A DNA nanomaterial consisting of DNA tetrahedron and aptamers, aggregation-induced emission luminogens, and antitumor drug doxorubicin, is fabricated and attached on the GO surface. This developed hybrid with good biocompatibility exhibits high selectivity to target liver cancer cells, and performs well in in vitro and in vivo liver tumor fluorescence imaging diagnosis and chemotherapy. Additionally, a GO-based fluorescent DNA nanodevice is also constructed by using microfluidic chips for liver tumor cell screening.
机译：基于荧光超细淤积率和目标识别能力，石墨烯氧化物（GO）基础的荧光DNA Aptasensors在生物测定中是有前途的纳米材料。 然而，他们的体内应用仍然是一个有吸引力，但重要的挑战性。 在这一贡献中，首次证明了肝肿瘤体内诊断和治疗的纳米材料。 由DNA四面体和适体组成的DNA纳米材料，聚集诱导的发光光学性和抗肿瘤药物多柔比蛋白，并连接在去表面上。 这种具有良好生物相容性的杂种具有高选择性对靶向肝癌细胞的选择性，并且在体外和体内肝肿瘤荧光显影诊断和化疗中表现良好。 另外，还通过使用用于肝肿瘤细胞筛选的微流体芯片来构建Go基荧光DNA纳米型。

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  • 来源
    《Advanced Functional Materials》 |2021年第36期|2102645.1-2102645.8|共8页
  • 作者

    Ma Ke; Xie Wei; Liu Wei; Wang Lei; Wang Dong; Tang Ben Zhong;

  • 作者单位

    Shenzhen Univ Ctr AIE Res Shenzhen Key Lab Polymer Sci & Technol Guangdong Res Ctr Interfacial Engn Funct Mat Coll Shenzhen 518060 Peoples R China|Shenzhen Univ Coll Optoelect Engn Key Lab Optoelect Devices & Syst Minist Educ & Guangdong Prov Shenzhen 518060 Peoples R China;

    Shenzhen Univ Ctr AIE Res Shenzhen Key Lab Polymer Sci & Technol Guangdong Res Ctr Interfacial Engn Funct Mat Coll Shenzhen 518060 Peoples R China|Shenzhen Univ Coll Optoelect Engn Key Lab Optoelect Devices & Syst Minist Educ & Guangdong Prov Shenzhen 518060 Peoples R China;

    Wuhan Univ Key Lab Artificial Micro & Nanostruct Minist Educ Sch Phys & Technol Wuhan 430072 Peoples R China;

    Shenzhen Univ Ctr AIE Res Shenzhen Key Lab Polymer Sci & Technol Guangdong Res Ctr Interfacial Engn Funct Mat Coll Shenzhen 518060 Peoples R China|Shenzhen Univ Coll Optoelect Engn Key Lab Optoelect Devices & Syst Minist Educ & Guangdong Prov Shenzhen 518060 Peoples R China;

    Shenzhen Univ Ctr AIE Res Shenzhen Key Lab Polymer Sci & Technol Guangdong Res Ctr Interfacial Engn Funct Mat Coll Shenzhen 518060 Peoples R China;

    Hong Kong Univ Sci & Technol Hong Kong Branch Chinese Natl Engn Res Ctr Tissue Restorat & Reconstruct Dept Chem Kowloon Clear Water Bay Hong Kong 999077 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    aggregation-induced emission; cancer theranostics; cell screening; DNA aptamers; DNA tetrahedron;

    机译：聚集诱导的发射;癌症治疗;细胞筛选;DNA适体;DNA四面体;

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