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Injectable Microfluidic Hydrogel Microspheres for Cell and Drug Delivery

机译:用于细胞和药物递送的可注射的微流体水凝胶微球

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摘要

Microfluidic hydrogel microspheres have been broadly studied across a wide range of industries and applications, and their use in the medical field, including control cells and drug delivery, is increasing. The usual design of these materials is intended to enable the efficient and smart encapsulation of cells and/or drugs in microspheres in which the functionalities and features are effectively controlled, lending itself some unique properties. These characteristics promote exchanges and cooperation in multiple disciplines and boost the development of precision medicine, new manufacturing technologies, and applied materials. This review begins with a discussion of microfluidic hydrogel microspheres and then introduces the preparation equipment, main principles, and related characteristics of the microspheres. Furthermore, the medical applications of microfluidic hydrogel microspheres for delivering cells and drugs are emphasized. Finally, this review discusses perspectives and future directions for accelerating the development and application of microfluidic hydrogel microspheres for controlled delivery.
机译:微流体水凝胶微球在各种行业和应用中广泛研究,它们在医学领域的使用,包括对照细胞和药物递送,正在增加。通常的这些材料的设计旨在实现微球中的细胞和/或药物的高效和智能封装,其中有效地控制功能和特征,贷款本身是一些独特的性质。这些特色促进了多学科的交流与合作,提高了精密药,新制造技术和应用材料的发展。该审查开始于对微流体水凝胶微球的讨论,然后介绍了微球的制备设备,主要原理和相关特征。此外,强调了微流体水凝胶微球的医学应用递送细胞和药物。最后,本综述讨论了加速微流体水凝胶微球进行控制递送的发展和应用的观点和未来方向。

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  • 来源
    《Advanced Functional Materials》 |2021年第31期|2103339.1-2103339.24|共24页
  • 作者单位

    Tongji Univ Sch Med Dept Orthopaed Shanghai Peoples Hosp 10 301 Middle Yanchang Rd Shanghai 200072 Peoples R China|Shanghai Jiao Tong Univ Shanghai Key Lab Prevent & Treatment Bone & Joint Shanghai Inst Traumatol & Orthopaed Dept Orthopaed Ruijin Hosp Sch Med 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent & Treatment Bone & Joint Shanghai Inst Traumatol & Orthopaed Dept Orthopaed Ruijin Hosp Sch Med 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent & Treatment Bone & Joint Shanghai Inst Traumatol & Orthopaed Dept Orthopaed Ruijin Hosp Sch Med 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

    Tongji Univ Sch Med Dept Orthopaed Shanghai Peoples Hosp 10 301 Middle Yanchang Rd Shanghai 200072 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent & Treatment Bone & Joint Shanghai Inst Traumatol & Orthopaed Dept Orthopaed Ruijin Hosp Sch Med 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent & Treatment Bone & Joint Shanghai Inst Traumatol & Orthopaed Dept Orthopaed Ruijin Hosp Sch Med 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

    Tongji Univ Sch Med Dept Orthopaed Shanghai Peoples Hosp 10 301 Middle Yanchang Rd Shanghai 200072 Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Key Lab Prevent & Treatment Bone & Joint Shanghai Inst Traumatol & Orthopaed Dept Orthopaed Ruijin Hosp Sch Med 197 Ruijin 2nd Rd Shanghai 200025 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomaterials; cell delivery; drug delivery; hydrogel microspheres; microfluidics;

    机译:生物材料;细胞输送;药物递送;水凝胶微球;微流体;

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