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Bioinspired Self-Assembling Materials for Modulating Enzyme Functions

机译：用于调节酶功能的生物透露自组装材料

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摘要

Enzymes tend to malfunction when they work out of their natural cellular environments. Engineering a favorable microenvironment around enzymes has emerged as an effective strategy to finely tune the enzymatic functions and reshape the biocatalytic activities. Supramolecular self-assembly provides a bottom-up approach for spatial arrangement of functional groups and fabrication of materials with tailorable local properties. In this review, the progress in designing, creating, and tailoring the enzyme microenvironments is discussed, with the bioinspired self-assembling materials as the scaffolds built from molecular building blocks. The relationship between the physicochemical properties and the local environments (pH, substrates, or hydration) of the scaffolds, and the catalytic properties of the scaffolded enzymes are focused upon. The power of the self-assembly to regulate the catalytic systems dynamically is also highlighted. In the end, an outlook on the obstacles, possible solutions, and future directions on the microenvironment engineering of enzymes is provided.
机译：当它们从自然蜂窝环境中工作时，酶往往发生故障。工程有良好的酶的微环境已经出现为精细调整酶促功能并重塑生物催化活动的有效策略。超分子自组装提供了官能团的空间布置和具有可定制局部特性的材料的自下而上的方法。在本文中，讨论了设计，创造和定制酶微环境的进展，并将生物悬浮的自组装材料作为由分子构建块构建的支架。重组物理化学性质与局部环境（PH，底物或水合）的关系，以及支架酶的催化性质。还突出了自组装来调节催化系统的动力。最后，提供了对酶微环境工程的障碍物，可能的解决方案和未来方向的展望。

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  • 来源
    《Advanced Functional Materials》 |2021年第38期|2104819.1-2104819.20|共20页
  • 作者

    Du Peidong; Xu Shichao; Xu Zhi-Kang; Wang Zhen-Gang;

  • 作者单位

    Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Key Lab Biomed Mat Nat Macromol Minist Educ Beijing Lab Biomed Mat Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Key Lab Biomed Mat Nat Macromol Minist Educ Beijing Lab Biomed Mat Beijing 100029 Peoples R China;

    Zhejiang Univ Dept Polymer Sci & Engn MOE Key Lab Macromol Synth & Functionalizat Hangzhou 310027 Peoples R China|Zhejiang Univ Dept Polymer Sci & Engn Key Lab Adsorpt & Separat Mat & Technol Zhejiang Hangzhou 310027 Peoples R China;

    Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Key Lab Biomed Mat Nat Macromol Minist Educ Beijing Lab Biomed Mat Beijing 100029 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biocatalysis; enzymes; microenvironment; scaffolds; self-assembly;

    机译：生物催化;酶;微环境;脚手架;自组装;

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