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首页> 外文期刊>Advanced Functional Materials >An Injectable Hydrogel for Simultaneous Photothermal Therapy and Photodynamic Therapy with Ultrahigh Efficiency Based on Carbon Dots and Modified Cellulose Nanocrystals
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An Injectable Hydrogel for Simultaneous Photothermal Therapy and Photodynamic Therapy with Ultrahigh Efficiency Based on Carbon Dots and Modified Cellulose Nanocrystals

机译：基于碳点和改性纤维素纳米晶体的超高效率同时光热疗法和光动力治疗的可注射水凝胶

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摘要

The convenience of injectable hydrogels that can provide high loading of diverse phototherapy agents and further long-time retention at the tumor site has attracted tremendous interest in simultaneous photothermal and photodynamic cancer therapies. However, to incorporate the phototherapy agents into hydrogels, complex modifications are generally unavoidable. Moreover, these phototherapy agents usually suffer from low efficiency and work at different irradiation wavelengths outside the near infrared windows. Hence, a method for the fabrication of an injectable hydrogel for simultaneous photothermal therapy and photodynamic therapy, through the Schiff-base reaction between amido modified carbon dots (NCDs) and aldehyde modified cellulose nanocrystals is proposed. The NCDs act as both phototherapy agents and crosslinkers to form hydrogels. Significantly, the NCDs demonstrate an extremely high photothermal conversion efficiency of 77.6% which is among the highest levels for photothermal agents and a high singlet quantum yield of 0.37 under a single 660 nm light-emitting diode irradiation. The hydrogels are examined through in vitro and in vivo animal experiments which show nontoxic and effectively tumor inhibition. Thus, the strategy of direct reaction of phototherapy agents and the matrix not only provides new strategies for injectable hydrogel fabrication but paves a new road for advanced tumor treatment.
机译：可在肿瘤部位提供高负荷的可注射水凝胶的便利性，并且在肿瘤部位进一步留下的长期保留引起了对同时光热和光动力学癌症疗法的巨大兴趣。然而，为了将光疗剂掺入水凝胶中，复杂的修饰通常是不可避免的。此外，这些光疗剂通常在近红外窗口外的不同照射波长下遭受低效率和工作。因此，提出了一种通过酰基碱基反应制备用于同时光热疗法和光动力治疗的可注射水凝胶的方法，通过酰胺改性的碳点（NCD）和醛改性纤维素纳米晶体之间的Schiff-Base反应。 NCDS充当光疗剂和交联剂以形成水凝胶。值得注意的是，NCD具有77.6％的极高的光热转化效率，其在单个660nm发光二极管照射下的光热试剂的最高水平和0.37的高单位量子收率。通过体外和体内动物实验检查水凝胶，其显示无毒，有效地肿瘤抑制。因此，光疗剂的直接反应和基质的策略不仅为注射水凝胶制造提供了新的策略，而是为先进的肿瘤治疗铺平了新道路。

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  • 来源
    《Advanced Functional Materials》 |2021年第45期|2106079.1-2106079.12|共12页
  • 作者

    Chen Tianxing; Yao Tengteng; Peng Hui; Whittaker Andrew K.; Li Yao; Zhu Shenmin; Wang Zhaoyang;

  • 作者单位

    Shanghai Pao Tong Univ State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Dept Ophthalmol Peoples Hosp 9 Sch Med Shanghai 200240 Peoples R China|Shanghai Key Lab Orbital Dis & Ocular Oncol Shanghai 200000 Peoples R China;

    Univ Queensland Australian Inst Bioengn & Nanotechnol Brisbane Qld 4072 Australia|Univ Queensland ARC Ctr Excellence Convergent Bionano Sci & Techn Brisbane Qld 4072 Australia;

    Univ Queensland Australian Inst Bioengn & Nanotechnol Brisbane Qld 4072 Australia|Univ Queensland ARC Ctr Excellence Convergent Bionano Sci & Techn Brisbane Qld 4072 Australia;

    Shanghai Pao Tong Univ State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China;

    Shanghai Pao Tong Univ State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Dept Ophthalmol Peoples Hosp 9 Sch Med Shanghai 200240 Peoples R China|Shanghai Key Lab Orbital Dis & Ocular Oncol Shanghai 200000 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    carbon dots; cellulose nanocrystals; injectable hydrogels; simultaneous photothermal therapy; photodynamic therapy;

    机译：碳点;纤维素纳米晶体;可注射水凝胶;同时光热疗法;光动力疗法;

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