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首页> 外文期刊>Advanced Functional Materials >Designing Squaraine Dyes with Bright Deep-Red Aggregation-Induced Emission for Specific and Ratiometric Fluorescent Detection of Hypochlorite
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Designing Squaraine Dyes with Bright Deep-Red Aggregation-Induced Emission for Specific and Ratiometric Fluorescent Detection of Hypochlorite

机译：用明亮深红色聚集诱导的次氯酸氯酸盐的特定和比率荧光检测设计Squaraine染料

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摘要

Development of ratiometric fluorescent hypochlorite probes with strong long wavelength fluorescence in aqueous medium, high resistance to photobleaching, high sensitivity and selectivity, and low biological toxicity remains a challenge. In this work, a molecular design strategy is proposed that can transform the traditional squaraine dyes (SQs) with aggregation-caused quenching character into aggregation-induced emission (AIE)-active luminogens by functionalizing the end-groups with tetraphenylethylene units and further introducing hydrophilic sulfonate group as the side chains. The resulting TPE-SQ5 not only emits strong deep-red fluorescence with a high quantum yield of 11.0% and high photostability, but more encouragingly can serve as a ratiometric fluorescent hypochlorite probe with high selectivity and sensitivity (detection limit: 5.6 nm), which indeed is the first report for SQs. The detailed sensing mechanism study demonstrates that the oxindole product with sulfonate substitution is responsible for the ratiometric fluorescent response. Furthermore, TPE-SQ5 nanoparticles with high biocompatibility and low cytotoxicity are successfully used for ratiometrically imaging exogenous and endogenous hypochlorite in living cells.
机译：在水性介质中具有强度长波长荧光的比率荧光次氯酸盐探针的研制，高抗光博抗性，高敏感性和选择性，以及低生物毒性仍然是一个挑战。在这项工作中，提出了一种分子设计策略，其可以通过用四苯基单元官能化并进一步引入亲水性，将传统的Squaraine染料（SQS）与聚集引起的猝灭性能转化为聚集诱导的发射（AIE） - 活性发光物。进一步引入亲水性磺酸盐组作为侧链。得到的TPE-SQ5不仅发射强烈的深红色荧光，高量子产率为11.0％和高的光稳定性，但更令人鼓舞的是，可以用作具有高选择性和灵敏度（检测极限：5.6nm）的比率荧光次氯酸盐探针（检测极限：5.6nm）实际上是SQS的第一个报告。详细的传感机制研究表明，氧吲哚产物具有磺酸盐取代的原因是荧光反应的原因。此外，具有高生物相容性和低细胞毒性的TPE-SQ5纳米颗粒被成功地用于在活细胞中成功用于几分异构成像外源和内源性次氯酸盐。

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  • 来源
    《Advanced Functional Materials》 |2021年第45期|2105452.1-2105452.10|共10页
  • 作者

    Qiao Weiguo; Ma Teng; Wang Shuangshuang; Li Longjie; Liu Miao; Jiang Hao; Wu Yuzhou; Zhu Jintao; Li Zhongan;

  • 作者单位

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

    Huazhong Univ Sci & Technol Sch Chem & Chem Engn Hubei Engn Res Ctr Biomat & Med Protect Mat Minist Educ Key Lab Mat Chem Energy Convers & Sto Wuhan 430074 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    aggregation-induced emission; deep-red cell imaging; hypochlorite detection; ratiometric fluorescent probes; squaraine dyes;

    机译：聚集诱导的发射;深红细胞成像;次氯酸盐检测;比例荧光探针;Squaraine染料;

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