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Application of Mannose-Functionalized Microgel as a Novel Vaccine Delivery Platform for Subunit Vaccines

机译：甘露糖官能化微凝胶作为亚基疫苗新型疫苗递送平台的应用

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摘要

The recent outbreaks of a series of new infectious diseases have highlighted the pressing need to develop efficacious countermeasures, including preventive vaccines. Subunit vaccines are developed using the subunit proteins from pathogens to induce immune responses, which are safe but often limited by low immunogenicity. Particulate vaccines can potentially enhance the endocytosis efficiency of antigen-presenting cells (APCs) and promote antigen delivery to the draining lymph nodes. Besides, the particulate vaccines that contain pathogen-associated molecular patterns can promote antigen-presenting by binding to pattern recognition receptors, thereby enhancing the efficacy of vaccination. Here, a new type of particulate subunit vaccine is developed, which is composed of model antigen ovalbumin and mannose-modified microgels. The microgels can prevent the degradation of the antigen and control the slow release of the encapsulate antigen in a sustained manner. The mannose modified on the microgels can target the mannose receptor of the APCs, further improving the endocytosis efficiency of APCs and promoting the effectiveness of the subunit vaccine. This study addresses that the mannose-modified microgel as a carrier can effectively promote the efficiency of the subunit vaccine, hence providing a promising platform for improving subunit vaccine.
机译：最近一系列新型传染病的爆发突出了强迫需要了解有效的对策，包括预防疫苗。使用来自病原体的亚基蛋白质开发亚基疫苗，以诱导免疫应答，这是安全的，但通常受低免疫原性的限制。颗粒状疫苗可以潜在地提高抗原呈递细胞（APC）的内吞作用效率，并促进抗原输送到排水淋巴结。此外，含有病原体相关分子模式的颗粒疫苗可以通过与模式识别受体结合而促进抗原呈递，从而提高疫苗接种的功效。这里，开发了一种新型的颗粒亚基疫苗，其由模型抗原卵蛋白和甘露糖改性的微凝胶组成。微凝胶可以防止抗原的降解并以持续的方式控制包封抗原的缓慢释放。在微胶凝中修饰的甘露糖可以靶向APC的甘露糖受体，进一步提高APC的内吞作用效率并促进亚基疫苗的有效性。本研究地址综合修饰的微凝胶作为载体可以有效地促进亚基疫苗的效率，因此为改善亚基疫苗提供有希望的平台。

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  • 来源
    《Advanced Functional Materials》 |2021年第45期|2105742.1-2105742.11|共11页
  • 作者

    Pan Yong; Qi Yanxin; Li Xiaoyuan; Luan Shifang; Huang Yubin;

  • 作者单位

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Polymer Phys & Chem Changchun 130022 Peoples R China|Univ Sci & Technol China Hefei 230026 Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Polymer Phys & Chem Changchun 130022 Peoples R China;

    Northeast Normal Univ Fac Chem Changchun 130024 Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Polymer Phys & Chem Changchun 130022 Peoples R China|Univ Sci & Technol China Hefei 230026 Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Polymer Phys & Chem Changchun 130022 Peoples R China|Northeast Normal Univ Fac Chem Changchun 130024 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antigen-presenting cells; mannose; microgels; subunit vaccines; target;

    机译：抗原呈递细胞;甘露糖;微凝块;亚基疫苗;目标;

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