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Biomimetic Lamellar Chitosan Scaffold for Soft Gingival Tissue Regeneration

机译：仿生层状壳聚糖支架用于软牙龈组织再生

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摘要

Mucogingival surgery has become a common procedure for soft gingival tissue reparation in dental clinical practice, which mainly relies on autograft or commercial collagen membranes (CM). However, the autograft faces grand challenges in source availability and long-term post-surgery pain management, and the CM is restricted by its poor mechanical properties in an aqueous environment. Here, it is reported that a bio-inspired lamellar chitosan scaffold (LCS) with long range ordered porous structure, manufactured through a bidirectional freezing method, can serve as a promising gingival tissue engineering material. The LCS not only exhibits excellent mechanical properties in the hydrated state but also accelerates vessel formation and soft tissue regeneration in vivo. Most interestingly, the LCS is found to be capable of inducing macrophage differentiation to M2 macrophages, which is thought to play an important role in tissue regeneration. These advantages combined with its easy and low-cost preparation process make the LCS a promising candidate for dental clinical applications.
机译：粘膜手术手术已成为牙科临床实践中软牙龈组织赔偿的常见程序，主要依赖于自体移植或商业胶原膜（CM）。然而，自体移植面临源可用性和长期手术后疼痛管理中的大挑战，厘米受其在水性环境中的差的机械性能的限制。这里，据报道，通过双向冷冻方法制造的具有长范围有序多孔结构的生物启发的层状壳聚糖支架（LCS）可以用作有前途的牙龈组织工程材料。 LCS不仅在水合状态下表现出优异的机械性能，而且还加速体内血管形成和软组织再生。最有意义的是，LCS被发现能够诱导巨噬细胞分化为M2巨噬细胞，这被认为在组织再生中发挥重要作用。这些优点结合其简单且低成本的制备过程使LCS成为牙科临床应用的有希望的候选者。

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  • 来源
    《Advanced Functional Materials》 |2021年第43期|2105348.1-2105348.12|共12页
  • 作者

    Feng Yanhuizhi; Gao Huai-Ling; Wu Di; Weng Yu-Teng; Wang Ze-Yu; Yu Shu-Hong; Wang Zuolin;

  • 作者单位

    Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Sch & Hosp Stomatol Dept Implantol Shanghai 200072 Peoples R China;

    Univ Sci & Technol China Anhui Engn Lab Biomimet Mat Div Nanomat & Chem Inst Biomimet Mat & Chem Inst Energy Hefei Natl L Dept Chem CAS Ctr Excellence Nanosci Hefei Compre Hefei 230026 Peoples R China;

    Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Sch & Hosp Stomatol Dept Implantol Shanghai 200072 Peoples R China;

    Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Sch & Hosp Stomatol Dept Implantol Shanghai 200072 Peoples R China;

    Univ Sci & Technol China Anhui Engn Lab Biomimet Mat Div Nanomat & Chem Inst Biomimet Mat & Chem Inst Energy Hefei Natl L Dept Chem CAS Ctr Excellence Nanosci Hefei Compre Hefei 230026 Peoples R China;

    Univ Sci & Technol China Anhui Engn Lab Biomimet Mat Div Nanomat & Chem Inst Biomimet Mat & Chem Inst Energy Hefei Natl L Dept Chem CAS Ctr Excellence Nanosci Hefei Compre Hefei 230026 Peoples R China;

    Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Sch & Hosp Stomatol Dept Implantol Shanghai 200072 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    bidirectional freezing; biomimetics; lamellar chitosan scaffolds; macrophage differentiation; soft tissue regeneration;

    机译：双向冻结;生物体;层状壳聚糖支架;巨噬细胞分化;软组织再生;

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