• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >A Compartmental Silica Nanoreactor for Multienzyme-Regulated Superactive Catalytic Therapy
【24h】

A Compartmental Silica Nanoreactor for Multienzyme-Regulated Superactive Catalytic Therapy

机译：用于多酶调节的高度催化疗法的分区二氧化硅纳米反应器

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many tumor therapies take advantage of upsetting the redox balance in tumor cells, but to do so requires excessive biochemical or physical attacks. The high-throughput simulation using multi-pathway techniques described herein can yield an increased efficacy in bio-oxidation. In this study, compartmental hierarchical nanoreactors are developed as an efficient multi-pathway singlet oxygen (O-1(2)) generation system for superactive biocatalytic tumor therapy. The penetrated super cavity and connected dual-mesopore channels of the compartmental multienzyme nanoreactors are designed using the proposed heterogeneous template assembly for multi-enzyme complex (superoxide dismutase (SOD)-lactoperoxidase (LPO)) and photosensitizer molecule (indocyanine green (ICG)) encapsulation. Benefiting by the enhanced direct substrate diffusion between the interacting SOD-LPO complex and decrease in external diffusion, the parallel catalysis combined by the superactive cascade biocatalysis and enzyme-promoted photosensitization effect is verified by this compartmental silica nanoreactor system. The parallel pathways not only make full use of the products of SOD (H2O2 and O-2), but also exhibit outstanding capability for O-1(2) production, at approximate to 2.15 and 1.70 times augmented O-1(2), respectively. Both in vitro and in vivo studies demonstrate the synergetic O-1(2)-mediated inhibition of tumor proliferation, lending this strategy great potential for the treatment of hypoxic tumors.
机译：许多肿瘤疗法利用扰乱肿瘤细胞的氧化还原平衡，但这样做需要过度的生化或物理攻击。使用本文所述的多途径技术的高通量模拟可以在生物氧化中产生增加的功效。在该研究中，分区分层纳米反应器是一种用于高级生物催化肿瘤治疗的有效多途径氧（O-1（2））生成系统。室内型多腔纳米反应器的穿透超腔和连接的双孔孔通道使用所提出的多酶复合物（超氧化物歧化酶（SOD） - 甲酰氧化酶（LPO））和光敏剂分子（吲哚菁绿（ICG））设计封装。通过增强的直接衬底扩散在相互作用的SOD-LPO复合物之间的扩散和外部扩散的降低，通过该隔间二氧化硅纳米反应器系统验证了通过增强级联生物分析和酶促进的光敏效果组合的平行催化。平行途径不仅可以充分利用SOD（H2O2和O-2）的产品，而且还表现出O-1（2）生产的突出能力，近似为2.15和1.70次增强O-1（2），分别。体外和体内研究都证明了协同o-1（2）介断的肿瘤增殖抑制，促使该策略潜在治疗缺氧肿瘤的潜力。

著录项

  • 来源
    《Advanced Functional Materials》 |2021年第43期|2103531.1-2103531.12|共12页
  • 作者

    Wu Chu; Qin Limei; Niu Dechao; Wang Xia; Zhang Qi; Shang Yinghui; Hu Min; Han Xiaoke; Shen Saiji; Qin Xing; Xi Songyan; Li Yongsheng; Wang Qigang;

  • 作者单位

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    East China Univ Sci & Technol Shanghai Engn Res Ctr Hierarch Nanomat Key Lab Ultrafine Mat Minist Educ Lab Lowdimens Mat Chem Sch Mat Sci & Engn Shanghai 200237 Peoples R China;

    East China Univ Sci & Technol Shanghai Engn Res Ctr Hierarch Nanomat Key Lab Ultrafine Mat Minist Educ Lab Lowdimens Mat Chem Sch Mat Sci & Engn Shanghai 200237 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    East China Univ Sci & Technol Shanghai Engn Res Ctr Hierarch Nanomat Key Lab Ultrafine Mat Minist Educ Lab Lowdimens Mat Chem Sch Mat Sci & Engn Shanghai 200237 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

    East China Univ Sci & Technol Shanghai Engn Res Ctr Hierarch Nanomat Key Lab Ultrafine Mat Minist Educ Lab Lowdimens Mat Chem Sch Mat Sci & Engn Shanghai 200237 Peoples R China;

    Tongji Univ Sch Chem Sci & Engn Shanghai 200092 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    anti-tumor activity; cascade enzyme catalysis; compartmental bioreactors; singlet oxygen;

    机译：抗肿瘤活性;级联酶催化;隔间生物反应器;单线氧;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号