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Customizing MR 1-Compatible Multifunctional Neural Interfaces through Fiber Drawing

机译：通过光纤绘图自定义MR 1兼容的多功能神经界面

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摘要

Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical, and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low-loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here, two fabrication approaches are introduced: 1) an iterative thermal drawing with a soft, low melting temperature (T-m) metal indium, and 2) a metal convergence drawing with traditionally non-drawable high T-m metal tungsten. Both approaches deliver multifunctional flexible neural interfaces with low-impedance metallic electrodes and low-loss waveguides, capable of recording optically-evoked and spontaneous neural activity in mice over several weeks. These fibers are coupled with a light-weight mechanical microdrive (1 g) that enables depth-specific interrogation of neural circuits in mice following chronic implantation. Finally, the compatibility of these fibers with magnetic resonance imaging is demonstrated and they are applied to visualize the delivery of chemical payloads through the integrated channels in real time. Together, these advances expand the domains of application of the fiber-based neural probes in neuroscience and neuroengineering.
机译：光纤绘图能够进行可伸缩的多功能柔性纤维制造，其集成电气，光学和微流体模态以记录和调节神经活动。然而，对材料的热机械性能的约束预防金属电极与低损耗聚合物波导的集成，用于同时电气记录和光学神经调节。这里，引入了两种制造方法：1）具有软，低熔点（T-M）金​​属铟的迭代热拉伸，2）金属收敛拉伸，其具有传统上不可吸附的高T-M金属钨。两种方法都具有低阻抗金属电极和低损耗波导的多功能柔性神经接口，能够在几周内记录在小鼠中的光学诱发和自发神经活性。这些纤维与轻质机械微直流（1g）偶联，其能够在慢性植入后小鼠中的神经电路询问。最后，证明了这些纤维与磁共振成像的兼容性，它们被应用于可视化通过集成通道的化学有效载荷的输送。这些进步在一起扩展了神经科学和神经衰老中的纤维基神经探针的应用领域。

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  • 来源
    《Advanced Functional Materials》 |2021年第43期|2104857.1-2104857.16|共16页
  • 作者

    Antonini Marc-Joseph; Sahasrabudhe Atharva; Tabet Anthony; Schwalm Miriam; Rosenfeld Dekel; Garwood Indie; Park Jimin; Loke Gabriel; Khudiyev Tural; Kanik Mehmet; Corbin Nathan; Canales Andres; Jasanoff Alan; Fink Yoel; Anikeeva Polina;

  • 作者单位

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA|Harvard MIT Hlth Sci & Technol Grad Program Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Chem Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Chem Engn Cambridge MA 02139 USA|MIT Koch Inst Integrat Canc Res 77 Massachusetts Ave Cambridge MA 02139 USA;

    MIT Dept Biol Engn 77 Massachusetts Ave Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA;

    Harvard MIT Hlth Sci & Technol Grad Program Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Mat Sci & Engn Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Mat Sci & Engn Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Mat Sci & Engn Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|Kinetik Therapeut LLC Newton MA 02459 USA;

    MIT Dept Chem Engn Cambridge MA 02139 USA;

    Adv Silicon Grp Lowell MA 01854 USA;

    MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Biol Engn 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Brain & Cognit Sci E25-618 Cambridge MA 02139 USA|MIT Dept Nucl Sci & Engn 77 Massachusetts Ave Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Mat Sci & Engn Cambridge MA 02139 USA|Adv Funct Fabr Amer Cambridge MA 02139 USA|MIT Inst Soldier Nanotechnol 77 Massachusetts Ave Cambridge MA 02139 USA;

    MIT Res Lab Elect 77 Massachusetts Ave Cambridge MA 02139 USA|MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA|MIT Dept Mat Sci & Engn Cambridge MA 02139 USA|MIT Dept Brain & Cognit Sci E25-618 Cambridge MA 02139 USA;

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  • 正文语种 eng
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  • 关键词

    fibers; magnetic resonance imaging; microdrives; multifunctional neural probes; thermal drawing;

    机译：纤维;磁共振成像;微探剂;多功能神经探头;热绘图;

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