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Ultrastable and Biocompatible NIR-II Quantum Dots for Functional Bioimaging

机译：用于功能性生物成像的超稳定且生物相容的NIR-II量子点

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1703451.1-1703451.13%Fluorescence bioimaging in the second near-infrared spectral region (NIR-II, 1000-1700 nm) can provide advantages of high spatial resolution and large penetration depth, due to low light scattering. However, NIR-II fluorophores simultaneously possessing high brightness, good stability, and biocompatibility are very rare. Hydrophobic NIR-II emissive PbS@CdS quantum dots (QDs) are surface-functionalized, via a silica and amphiphilic polymer (Pluronic F-127) dual-layer coating method. The as-synthesized PbS@CdS@SiO2@F-127 nanoparticles (NPs) are aqueously dispersible and possess a quantum yield of approximate to 5.79%, which is much larger than those of most existing NIR-II fluorophores. Thanks to the dual-layer protection, PbS@CdS@SiO2@F-127 NPs show excellent chemical stability in a wide range of pH values. The biocompatibility of PbS@CdS@SiO2@F-127 NPs is studied, and the results show that the toxicity of the NPs in vivo could be minimal. PbS@CdS@SiO2@F-127 NPs are then utilized for in vivo and real-time NIR-II fluorescence microscopic imaging of mouse brain. The architecture of blood vessels is visualized and the imaging depth reaches 950 mu m. Furthermore, in vivo NIR-II fluorescence imaging of gastrointestinal tract is achieved, by perfusing PbS@CdS@SiO2@F-127 NPs into mice at a rather low dosage. This work illustrates the potential of ultrastable, biocompatible, and bright NIR-II QDs in biomedical and clinical applications, which require deep tissue imaging.
机译：1703451.1-1703451.13％在第二个近红外光谱区域（NIR-II，1000-1700 nm）中的荧光生物成像由于光散射低，可以提供高空间分辨率和大穿透深度的优势。然而，同时具有高亮度，良好的稳定性和生物相容性的NIR-II荧光团非常罕见。疏水性NIR-II发射性PbS @ CdS量子点（QDs）通过二氧化硅和两亲性聚合物（Pluronic F-127）双层涂覆方法进行表面官能化。合成后的PbS @ CdS @ SiO2 @ F-127纳米颗粒（NPs）具有水分散性，量子产率约为5.79％，比大多数现有的NIR-II荧光团大得多。归功于双层保护，PbS @ CdS @ SiO2 @ F-127 NP在广泛的pH值范围内均表现出出色的化学稳定性。研究了PbS @ CdS @ SiO2 @ F-127 NPs的生物相容性，结果表明该NPs在体内的毒性极小。然后将PbS @ CdS @ SiO2 @ F-127 NP用于小鼠脑的体内和实时NIR-II荧光显微成像。可视化血管的结构，成像深度达到950微米。此外，通过以相当低的剂量将PbS @ CdS @ SiO2 @ F-127 NPs灌注到小鼠体内，可以实现胃肠道的体内NIR-II荧光成像。这项工作说明了在需要深层组织成像的生物医学和临床应用中，超稳定，生物相容性强且明亮的NIR-II QD的潜力。

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  • 来源
    《Advanced Functional Materials》 |2018年第9期|161-173|共13页
  • 作者

    Zebibula Abudureheman; Alifu Nuernisha; Xia Liqun; Sun Chaowei; Yu Xiaoming; Xue Dingwei; Liu Liwei; Li Gonghui; Qian Jun;

  • 作者单位

    Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Urol, Hangzhou 310058, Zhejiang, Peoples R China;

    Zhejiang Univ, JORCEP SinoSwedish Joint Res Ctr Photon, State Key Lab Modern Opt Instrumentat, Ctr Opt & Electromagnet Res, Hangzhou 310058, Zhejiang, Peoples R China;

    Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Urol, Hangzhou 310058, Zhejiang, Peoples R China;

    Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Urol, Hangzhou 310058, Zhejiang, Peoples R China;

    Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Urol, Hangzhou 310058, Zhejiang, Peoples R China;

    Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Guangdong, Peoples R China;

    Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Urol, Hangzhou 310058, Zhejiang, Peoples R China;

    Zhejiang Univ, JORCEP SinoSwedish Joint Res Ctr Photon, State Key Lab Modern Opt Instrumentat, Ctr Opt & Electromagnet Res, Hangzhou 310058, Zhejiang, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    brain vascular imaging; gastrointestinal tract imaging; in vivo imaging; NIR-II fluorescence imaging; quantum dots;

    机译：脑血管成像;胃肠道成像;体内成像;NIR-II荧光成像;量子点;

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