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Photogenerated Aldehydes for Protein Patterns on Hydrogels and Guidance of Cell Behavior

机译：光生醛在水凝胶上的蛋白质模式和细胞行为的指导

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摘要

The immobilization of proteins to hydrogels is important and plays a significant role to provide suitable biomimetic material as extracellular matrix for cell behavior mediation. This study describes a novel and universal strategy for photopatterning unmodified proteins on hydrogels. The methodology creates photogenerated aldehyde regions within a protein-resistant hydrogel and then conjugates unmodified proteins by mild imine ligation with spatial, temporal, and dosage control. The relatively stable aldehyde intermediate enables the facile and highly efficient covalent immobilization of proteins by a postfunctionalization methodology and the sequential protein patterns provide an easy access to control the identity and dynamic change of proteins presented to cells on demand, thus mediating cell behaviors. This approach provides important opportunities for understanding and controlling cell behavior mediated by proteins, and opens up new avenues for hydrogels in tissue engineering and biotechnology applications.
机译：将蛋白质固定在水凝胶上很重要，并且在提供合适的仿生材料作为细胞行为介导的细胞外基质方面发挥着重要作用。这项研究描述了一种新的通用策略，用于在水凝胶上对未修饰的蛋白质进行光图案化。该方法在抗蛋白质的水凝胶中产生光生醛区域，然后通过温和的亚胺连接，空间，时间和剂量控制来缀合未修饰的蛋白质。相对稳定的醛中间体可通过后功能化方法实现蛋白质的便捷高效高效共价固定，并且连续的蛋白质模式可轻松控制需要时呈现给细胞的蛋白质的身份和动态变化，从而介导细胞行为。这种方法为理解和控制蛋白质介导的细胞行为提供了重要机会，并为组织工程和生物技术应用中的水凝胶开辟了新途径。

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  • 来源
    《Advanced Functional Materials》 |2018年第14期|1706918.1-1706918.9|共9页
  • 作者

    Ming Zunzhen; Fan Jinyan; Bao Chunyan; Xue Yuan; Lin Qiuning; Zhu Linyong;

  • 作者单位

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;

    East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    cell behavior; covalent conjugation; hydrogels; postfunctionalization; protein photopatterns;

    机译：细胞行为;共价共轭;水凝胶;后功能化;蛋白质光图案;

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