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MRI-Visible siRNA Nanomedicine Directing Neuronal Differentiation of Neural Stem Cells in Stroke

机译：MRI可视化siRNA纳米药物指导中风神经干细胞的神经元分化

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摘要

A major challenge in stroke treatment is the restoration of neural circuit in which neuron function plays a central role. Although transplantation of exogenous neural stem cells (NSCs) is admittedly a promising therapeutical means, the treatment outcome is greatly affected due to the poor NSCs differentiation into neurons caused by myelin associated inhibitory factors binding to Nogo-66 receptor (NgR). Herein, a nanoscale polymersome is developed to codeliver superparamagnetic iron oxide nanoparticles and siRNA targeting NgR gene (siNgR) into NSCs. This multifunctional nanomedicine directs neuronal differentiation of NSCs through silencing the NgR gene and meanwhile allows a noninvasive monitoring of NSC migration with magnetic resonance imaging. An improved recovery of neural function is achieved in rat ischemic stroke model. The results demonstrate the great potential of the multifunctional siRNA nanomedicine in stroke treatment based on stem cell transplantation.
机译：中风治疗中的主要挑战是神经回路的恢复，其中神经元功能起着核心作用。尽管公认外源性神经干细胞（NSCs）的移植是一种有前途的治疗手段，但由于与Nogo-66受体（NgR）结合的髓磷脂相关抑制因子导致的NSCs向神经元的分化差，治疗结果受到了很大影响。在本文中，开发了纳米级聚合物囊泡，以将超顺磁性氧化铁纳米颗粒和靶向NgR基因（siNgR）的siRNA编码到NSC中。这种多功能的纳米药物通过沉默NgR基因来指导NSC的神经元分化，同时允许通过磁共振成像对NSC迁移进行无创监测。在大鼠缺血性中风模型中实现了神经功能的改善恢复。结果表明多功能siRNA纳米药物在基于干细胞移植的中风治疗中具有巨大的潜力。

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  • 来源
    《Advanced Functional Materials》 |2018年第14期|1706769.1-1706769.12|共12页
  • 作者

    Lu Liejing; Wang Yong; Zhang Fang; Chen Meiwei; Lin Bingling; Duan Xiaohui; Cao Minghui; Zheng Chushan; Mao Jiaji; Shuai Xintao; Shen Jun;

  • 作者单位

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Mat Sci & Engn, PCFM Lab, Minist Educ, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Mat Sci & Engn, PCFM Lab, Minist Educ, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, Guangzhou 510120, Guangdong, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    ischemic stroke; magnetic resonance imaging; multifunctional nanomedicine; neural stem cell transplantation; RNA interference;

    机译：缺血性中风;磁共振成像;多功能纳米药物;神经干细胞移植;RNA干扰;

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