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首页> 外文期刊>Advanced Functional Materials >Dendritic Fe_3O_4@ Poly(dopamine)@PAMAM Nanocomposite as Controllable NO-Releasing Material: A Synergistic Photothermal and NO Antibacterial Study
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Dendritic Fe_3O_4@ Poly(dopamine)@PAMAM Nanocomposite as Controllable NO-Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

机译：树突状Fe_3O_4 @聚（多巴胺）@PAMAM纳米复合材料作为可控NO释放材料：协同光热和NO抗菌研究

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摘要

Nowadays, antibiotic abuse increases the emergence of multidrug-resistant bacterial strains, which is the major reason for the failure of conventional antibiotic therapies. Therefore, developing novel antibacterial materials or therapies is an urgent demand. In the present study, photothermal and NO-releasing properties are integrated into a single nanocomposite to realize more efficient bactericidal effects. To this end, polydopamine (PDA) coated iron oxide nanocomposite (Fe3O4@PDA) is used as a photoconversion agent and the core, first three generation dendritic poly(amidoamine) (PAMAM-G3) is grafted on the surface of Fe3O4@PDA, and subsequently NO is loaded with the formation of NONOate. The resultant Fe3O4@PDA@PAMAM@NONOate displays controllable NO release property under intermittent 808 nm laser irradiation and excellent bacteria-separation efficiency. Moreover, excellent synergistic photothermal and NO antibacterial effects are observed against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, where bacterial viability and biofilm are significantly reduced. An antibacterial mechanism study reveals that the materials first adsorb onto the bacterial membrane, then cause damage to the membrane by the increased local temperature and the released NO under laser irradiation conditions, finally leak the intracellular components like DNA and induce bacteria death. The work provides a novel way for designing of antibacterial materials with higher efficiency.
机译：如今，抗生素滥用增加了多药耐药菌的出现，这是常规抗生素治疗失败的主要原因。因此，迫切需要开发新型的抗菌材料或疗法。在本研究中，将光热和NO释放特性集成到单个纳米复合材料中，以实现更有效的杀菌效果。为此，将聚多巴胺（PDA）包覆的氧化铁纳米复合材料（Fe3O4 @ PDA）用作光转化剂，并将芯体，首先将第三代树状聚（酰胺基胺）（PAMAM-G3）接枝到Fe3O4 @ PDA的表面，随后，NO会形成NONOate。生成的Fe3O4 @ PDA @ PAMAM @ NONOate在间歇性808 nm激光照射下显示出可控的NO释放性能，并具有出色的细菌分离效率。此外，对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌均观察到极好的协同光热和NO抗菌作用，这些细菌的生存能力和生物膜均明显降低。一项抗菌机制研究表明，该材料首先吸附到细菌膜上，然后在激光照射条件下因局部温度升高和释放的NO引起膜破坏，最后泄漏DNA等细胞内成分并导致细菌死亡。这项工作为高效设计抗菌材料提供了一种新颖的方法。

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  • 来源
    《Advanced Functional Materials》 |2018年第20期|1707440.1-1707440.14|共14页
  • 作者

    Yu Siming; Li Guowei; Liu Rui; Ma Dong; Xue Wei;

  • 作者单位

    Jinan Univ, Dept Biomed Engn, Guangdong Higher Educ Inst, Key Lab Biomat, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Biomed Engn, Guangdong Higher Educ Inst, Key Lab Biomat, Guangzhou 510632, Guangdong, Peoples R China;

    Tongji Univ, Key Lab Adv Civil Engn Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China;

    Jinan Univ, Dept Biomed Engn, Guangdong Higher Educ Inst, Key Lab Biomat, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Biomed Engn, Guangdong Higher Educ Inst, Key Lab Biomat, Guangzhou 510632, Guangdong, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    NO release; photothermal effects; poly(amidoamine) dendrimers; polydopamine-coated iron oxide nanoparticles; synergistic antibacterial effects;

    机译：NO释放;光热效应;聚（酰胺胺）树枝状大分子;聚多巴胺包覆的氧化铁纳米粒子;协同抗菌作用;

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