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首页> 外文期刊>Advanced Functional Materials >Biomimetic Ultralight, Highly Porous, Shape-Adjustable, and Biocompatible 3D Graphene Minerals via Incorporation of Self-Assembled Peptide Nanosheets
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Biomimetic Ultralight, Highly Porous, Shape-Adjustable, and Biocompatible 3D Graphene Minerals via Incorporation of Self-Assembled Peptide Nanosheets

机译：仿生超轻，高度多孔，形状可调和生物相容性3D石墨烯矿物，通过掺入自组装肽纳米片实现

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摘要

Hybrid nanomaterials with tailored functions, consisting of self-assembled peptides, are intensively applied in nanotechnology, tissue engineering, and biomedical applications due to their unique structures and properties. Herein, a peptide-mediated biomimetic strategy is adopted to create the multifunctional 3D graphene foam (GF)-based hybrid minerals. First, 2D peptide nanosheets (PNSs), obtained by self-assembling a motif-specific peptide molecule (LLVFGAKMLPHHGA), are expected to exhibit biofunctionality, such as the biomimetic mineralization of hydroxyapatite (HA) minerals. Subsequently, the noncovalent conjugation of PNSs onto GF support is utilized to form 3D GF-PNSs hybrid scaffolds, which are suitable for the growth of HA minerals. The fabricated biomimetic 3D GF-PNSs-HA minerals exhibit adjustable shape, superlow weight (0.017 g cm(-3)), high porosity (5.17 m(2) g(-1)), and excellent biocompatibility, proving potential applications in both bone tissue engineering and biomedical engineering. To the best of the authors' knowledge, it is the first time to combine 2D PNSs and GF to fabricate 3D organic-inorganic hybrid scaffold. Further development of these hybrid GF-PNSs scaffolds can potentially lead to materials used as matrices for drug delivery or bone tissue engineering as proven via successful 3D scaffold formation exhibiting interconnected pore-size structures suitable for vascularization and medium transport.
机译：具有定制功能的杂化纳米材料，由自组装肽组成，由于其独特的结构和特性，被广泛应用于纳米技术，组织工程和生物医学应用中。在本文中，采用肽介导的仿生策略来创建基于多功能3D石墨烯泡沫（GF）的混合矿物。首先，通过自组装基序特异性肽分子（LLVFGAKMLPHHGA）获得的2D肽纳米片（PNS）有望表现出生物功能，例如羟基磷灰石（HA）矿物的仿生矿化。随后，将PNSs与GF支持物的非共价结合用于形成3D GF-PNSs混合支架，该支架适合用于HA矿物质的生长。制成的仿生3D GF-PNSs-HA矿物具有可调节的形状，超轻的重量（0.017 g cm（-3）），高的孔隙率（5.17 m（2）g（-1））和出色的生物相容性，在这两种领域均具有潜在的应用前景骨组织工程和生物医学工程。据作者所知，这是第一次将2D PNS和GF结合起来制造3D有机-无机混合支架。这些混合的GF-PNSs支架的进一步发展可能潜在地导致用作药物递送或骨组织工程的基质的材料，这已通过成功的3D支架形成而得到证明，该3D支架显示出适合血管化和介质运输的互连孔径结构。

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  • 来源
    《Advanced Functional Materials》 |2018年第29期|1801056.1-1801056.10|共10页
  • 作者

    Li Keheng; Zhang Zhenfang; Li Dapeng; Zhang Wensi; Yu Xiaoqing; Liu Wei; Gong Coucong; Wei Gang; Su Zhiqiang;

  • 作者单位

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

    Univ Bremen, Fac Prod Engn, D-28359 Bremen, Germany;

    Univ Bremen, Fac Prod Engn, D-28359 Bremen, Germany;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    biomimetic mineralization; graphene; nanosheets; peptides; self-assembly;

    机译：仿生矿化石墨烯纳米片肽自组装;

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